Maryam Mardan-Nik1, Alireza Pasdar2,3, Khadijeh Jamialahmadi4,5, Amir Avan2, Mohsen Mohebati1, Habibollah Esmaily6, Atefeh Biabangard-Zak7, Fahimeh Afzal Javan8, Mahdi Rivandi8, Gordon A Ferns9, Majid Ghayour-Mobarhan10. 1. a Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran. 2. b Department of Modern Sciences and Technologies , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran. 3. c Division of Applied Medicine , Medical School, University of Aberdeen , Foresterhill , Aberdeen , UK. 4. d Department of Medical Biotechnology , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran. 5. e Biotechnology Research Center, Mashhad University of Medical Sciences , Mashhad , Iran. 6. f Department of Biostatistics and Epidemiology , School of Health, Mashhad University of Medical Sciences , Mashhad , Iran. 7. g Department of Biochemistry , Golestan University , Gorgan , Iran. 8. h Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran. 9. i Brighton & Sussex Medical School, Division of Medical Education , Falmer , Brighton , Sussex , UK. 10. j Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
Abstract
BACKGROUND: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. AIM: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. SUBJECTS AND METHODS: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. RESULTS: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. CONCLUSION: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.
BACKGROUND:Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. AIM: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. SUBJECTS AND METHODS: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. RESULTS: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. CONCLUSION: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.