Literature DB >> 26728073

[Wound healing in the elderly].

S A Eming1, M Wlaschek2, K Scharffetter-Kochanek3.   

Abstract

Restoration of tissue integrity is essential for host defense and protection of the organism. The efficacy and quality of skin repair varies significantly over a person's lifetime. Whereas prenatal wound healing is characterized by regeneration and scarless healing, scarring, fibrosis, and loss of function are features of postnatal repair. In fact, aging is the prominent risk factor for chronic wounds, skin fragility, infections, comorbidities, and decreased quality of life. Current strategies for restoration of tissue integrity and wound therapy are not sufficient and require further investigation of the underlying pathomechanisms and the development of causal-based concepts.

Entities:  

Keywords:  Aging; Fibrosis; Regeneration; Scarring; Skin

Mesh：

Year:  2016        PMID： 26728073     DOI： 10.1007/s00105-015-3738-2

Source DB:  PubMed          Journal:  Hautarzt        ISSN： 0017-8470            Impact factor:   0.751


  43 in total

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Authors:  W O Seiler
Journal:  Krankenpfl J       Date:  2000-06

2.  Selective pick-up of increased iron by deferoxamine-coupled cellulose abrogates the iron-driven induction of matrix-degrading metalloproteinase 1 and lipid peroxidation in human dermal fibroblasts in vitro: a new dressing concept.

Authors:  J Wenk; A Foitzik; V Achterberg; A Sabiwalsky; J Dissemond; C Meewes; A Reitz; P Brenneisen; M Wlaschek; W Meyer-Ingold; K Scharffetter-Kochanek
Journal:  J Invest Dermatol       Date:  2001-06       Impact factor: 8.551

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Authors:  D HARMAN
Journal:  J Gerontol       Date:  1956-07

4.  [Skin aging: Molecular understanding of extrinsic and intrinsic processes].

Authors:  E Makrantonaki; M Vogel; K Scharffetter-Kochanek; C C Zouboulis
Journal:  Hautarzt       Date:  2015-10       Impact factor: 0.751

5.  Venous leg ulcer: incidence and prevalence in the elderly.

Authors:  David J Margolis; Warren Bilker; Jill Santanna; Mona Baumgarten
Journal:  J Am Acad Dermatol       Date:  2002-03       Impact factor: 11.527

6.  Chronic wound repair and healing in older adults: current status and future research.

Authors:  Lisa Gould; Peter Abadir; Harold Brem; Marissa Carter; Teresa Conner-Kerr; Jeff Davidson; Luisa DiPietro; Vincent Falanga; Caroline Fife; Sue Gardner; Elizabeth Grice; John Harmon; William R Hazzard; Kevin P High; Pamela Houghton; Nasreen Jacobson; Robert S Kirsner; Elizabeth J Kovacs; David Margolis; Frances McFarland Horne; May J Reed; Dennis H Sullivan; Stephen Thom; Marjana Tomic-Canic; Jeremy Walston; JoAnne Whitney; John Williams; Susan Zieman; Kenneth Schmader
Journal:  Wound Repair Regen       Date:  2015-02-13       Impact factor: 3.617

7.  Human skin wounds: a major and snowballing threat to public health and the economy.

Authors:  Chandan K Sen; Gayle M Gordillo; Sashwati Roy; Robert Kirsner; Lynn Lambert; Thomas K Hunt; Finn Gottrup; Geoffrey C Gurtner; Michael T Longaker
Journal:  Wound Repair Regen       Date:  2009 Nov-Dec       Impact factor: 3.617

Review 8.  Mitochondrial ROS signaling in organismal homeostasis.

Authors:  Gerald S Shadel; Tamas L Horvath
Journal:  Cell       Date:  2015-10-22       Impact factor: 41.582

Review 9.  Clinical implications of gene polymorphisms in venous leg ulcer: a model in tissue injury and reparative process.

Authors:  Paolo Zamboni; Donato Gemmati
Journal:  Thromb Haemost       Date:  2007-07       Impact factor: 5.249

Review 10.  Mitochondria as signaling organelles.

Authors:  Navdeep S Chandel
Journal:  BMC Biol       Date:  2014-05-27       Impact factor: 7.431
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  1 in total

Review 1.  Divergent Sepsis Pathophysiology in Older Adults.

Authors:  Meagan S Kingren; Marlene E Starr; Hiroshi Saito
Journal:  Antioxid Redox Signal       Date:  2021-10-01       Impact factor: 8.401
  1 in total

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