| Literature DB >> 26726120 |
Abhishek Banerjee1, Rylan S Larsen2, Benjamin D Philpot3, Ole Paulsen4.
Abstract
Presynaptic NMDA receptors (preNMDARs) play pivotal roles in excitatory neurotransmission and synaptic plasticity. They facilitate presynaptic neurotransmitter release and modulate mechanisms controlling synaptic maturation and plasticity during formative periods of brain development. There is an increasing understanding of the roles of preNMDARs in experience-dependent synaptic and circuit-specific computation. In this review we summarize the latest understanding of compartment-specific expression and function of preNMDARs, and how they contribute to synapse-specific and circuit-level information processing.Entities:
Keywords: NMDA receptors; cortex; development; synaptic plasticity
Mesh:
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Year: 2015 PMID: 26726120 PMCID: PMC4716805 DOI: 10.1016/j.tins.2015.11.001
Source DB: PubMed Journal: Trends Neurosci ISSN: 0166-2236 Impact factor: 13.837