Literature DB >> 26725234

Biological activity of a polypeptide modulator of TRPV1 receptor.

I A Dyachenko1, Ya A Andreev2, Yu A Logashina3, A N Murashev4, E V Grishin5.   

Abstract

This paper presents data on the activity of a new APHC2 polypeptide modulator of TRPV1 receptors, which was isolated from the sea anemone Heteractis crispa. It has been shown that APHC2 has an analgesic activity, does not impair normal motor activity, and does not change body temperature of experimental animals, which has a great practical value for design of potent analgesics of a new generation. Further study of the characteristics of binding of the polypeptide to the TRPV1 receptor may show approaches to the development of other antagonists of this receptor that do not influence the body temperature.

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Year:  2016        PMID： 26725234     DOI： 10.1134/S0012496615060034

Source DB:  PubMed          Journal:  Dokl Biol Sci        ISSN： 0012-4966


  9 in total

Review 1.  Molecules to selectively target receptors for treatment of pain and neurogenic inflammation.

Authors:  Yaroslav A Andreev; Alexander A Vassilevski; Sergey A Kozlov
Journal:  Recent Pat Inflamm Allergy Drug Discov       Date:  2012-01

2.  AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.

Authors:  Narender R Gavva; Rami Tamir; Yusheng Qu; Lana Klionsky; T J Zhang; David Immke; Judy Wang; Dawn Zhu; Todd W Vanderah; Frank Porreca; Elizabeth M Doherty; Mark H Norman; Kenneth D Wild; Anthony W Bannon; Jean-Claude Louis; James J S Treanor
Journal:  J Pharmacol Exp Ther       Date:  2004-12-22       Impact factor: 4.030

3.  Analgesic effect of a polypeptide inhibitor of the TRPV1 receptor in noxious heat pain models.

Authors:  Y A Andreev; S A Kozlov; E P Kozlovskaya; E V Grishin
Journal:  Dokl Biochem Biophys       Date:  2009 Jan-Feb       Impact factor: 0.788

4.  Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1).

Authors:  Yaroslav A Andreev; Sergey A Kozlov; Sergey G Koshelev; Ekaterina A Ivanova; Margarita M Monastyrnaya; Emma P Kozlovskaya; Eugene V Grishin
Journal:  J Biol Chem       Date:  2008-06-25       Impact factor: 5.157

5.  Cyanogen bromide cleavage of proteins in salt and buffer solutions.

Authors:  Yaroslav A Andreev; Sergey A Kozlov; Alexander A Vassilevski; Eugene V Grishin
Journal:  Anal Biochem       Date:  2010-07-27       Impact factor: 3.365

6.  Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

Authors:  M J Caterina; A Leffler; A B Malmberg; W J Martin; J Trafton; K R Petersen-Zeitz; M Koltzenburg; A I Basbaum; D Julius
Journal:  Science       Date:  2000-04-14       Impact factor: 47.728

7.  Modulation of TRPV1-dependent contractility of normal and diabetic bladder smooth muscle by analgesic toxins from sea anemone Heteractis crispa.

Authors:  Igor B Philyppov; Oksana N Paduraru; Yaroslav A Andreev; Eugene V Grishin; Yaroslav M Shuba
Journal:  Life Sci       Date:  2012-09-12       Impact factor: 5.037

Review 8.  The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept.

Authors:  Arpad Szallasi; Daniel N Cortright; Charles A Blum; Samer R Eid
Journal:  Nat Rev Drug Discov       Date:  2007-05       Impact factor: 84.694

9.  Polypeptide modulators of TRPV1 produce analgesia without hyperthermia.

Authors:  Yaroslav A Andreev; Sergey A Kozlov; Yuliya V Korolkova; Igor A Dyachenko; Dmitrii A Bondarenko; Denis I Skobtsov; Arkadii N Murashev; Polina D Kotova; Olga A Rogachevskaja; Natalia V Kabanova; Stanislav S Kolesnikov; Eugene V Grishin
Journal:  Mar Drugs       Date:  2013-12-16       Impact factor: 5.118
  9 in total
  4 in total

1.  Effect of polypeptides from sea anemone Heteractis crispa on the rodent blood pressure, heart rate, and hemostasis.

Authors:  L A Skobtsova; I A Dyachenko; Ya A Andreev; Yu A Logashina; A N Murashev; E V Grishin
Journal:  Dokl Biol Sci       Date:  2016-11-08

Review 2.  Venom Peptide Toxins Targeting the Outer Pore Region of Transient Receptor Potential Vanilloid 1 in Pain: Implications for Analgesic Drug Development.

Authors:  Sung-Min Hwang; Youn-Yi Jo; Cinder Faith Cohen; Yong-Ho Kim; Temugin Berta; Chul-Kyu Park
Journal:  Int J Mol Sci       Date:  2022-05-21       Impact factor: 6.208

3.  Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor.

Authors:  Margarita Monastyrnaya; Steve Peigneur; Elena Zelepuga; Oksana Sintsova; Irina Gladkikh; Elena Leychenko; Marina Isaeva; Jan Tytgat; Emma Kozlovskaya
Journal:  Mar Drugs       Date:  2016-12-15       Impact factor: 5.118

4.  A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers.

Authors:  Jieon Lee; Bo-Hyung Kim; Kyung-Sang Yu; Hee Sun Kim; Ji Duck Kim; Joo-Youn Cho; SeungHwan Lee; Namyi Gu
Journal:  Drug Des Devel Ther       Date:  2017-04-24       Impact factor: 4.162
  4 in total

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