Rebecca Kerestes1, Anna Maria Segreti2, Lisa A Pan2, Mary L Phillips3, Boris Birmaher2, David A Brent2, Cecile D Ladouceur4. 1. Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, Australia. 2. Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. 3. Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA; Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK. 4. Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. Electronic address: ladouceurcd@upmc.edu.
Abstract
BACKGROUND: There is accumulating evidence of alterations in neural circuitry underlying the processing of social-affective information in adolescent Major Depressive Disorder (MDD). However the extent to which such alterations are present in youth at risk for mood disorders remains unclear. METHOD: Whole-brain blood oxygenation level-dependent task responses and functional connectivity using generalized psychophysiological interaction (gPPI) analyses to mild and intense happy face stimuli was examined in 29 adolescents with MDD (MDD; M age, 16.0, S.D. 1.2 years), 38 healthy adolescents at risk of a mood disorder, by virtue of having a parent diagnosed with either Bipolar Disorder (BD) or MDD (Mood-risk; M age 13.4, S.D. 2.5 years) and 43 healthy control adolescents, having parents with no psychiatric disorder (HC; M age 14.6, S.D. 2.2 years). RESULTS: Relative to HC adolescents, Mood-risk adolescents showed elevated right dorsolateral prefrontal cortex (DLPFC) activation to 100% intensity happy (vs. neutral) faces and concomitant lowered ventral putamen activity to 50% intensity happy (vs. neutral) faces. gPPI analyses revealed that MDD adolescents showed significantly lower right DLPFC functional connectivity with the ventrolateral PFC (VLPFC) compared to HC to all happy faces. LIMITATIONS: The current study is limited by the smaller number of healthy offspring at risk for MDD compared to BD. CONCLUSIONS: Because Mood-risk adolescents were healthy at the time of the scan, elevated DLPFC and lowered ventral striatal activity in Mood-risk adolescents may be associated with risk or resiliency. In contrast, altered DLPFC-VLPFC functional connectivity in MDD adolescents may be associated with depressed mood state. Such alterations may affect social-affective development and progression to a mood disorder in Mood-risk adolescents. Future longitudinal follow-up studies are needed to directly answer this research question.
BACKGROUND: There is accumulating evidence of alterations in neural circuitry underlying the processing of social-affective information in adolescent Major Depressive Disorder (MDD). However the extent to which such alterations are present in youth at risk for mood disorders remains unclear. METHOD: Whole-brain blood oxygenation level-dependent task responses and functional connectivity using generalized psychophysiological interaction (gPPI) analyses to mild and intense happy face stimuli was examined in 29 adolescents with MDD (MDD; M age, 16.0, S.D. 1.2 years), 38 healthy adolescents at risk of a mood disorder, by virtue of having a parent diagnosed with either Bipolar Disorder (BD) or MDD (Mood-risk; M age 13.4, S.D. 2.5 years) and 43 healthy control adolescents, having parents with no psychiatric disorder (HC; M age 14.6, S.D. 2.2 years). RESULTS: Relative to HC adolescents, Mood-risk adolescents showed elevated right dorsolateral prefrontal cortex (DLPFC) activation to 100% intensity happy (vs. neutral) faces and concomitant lowered ventral putamen activity to 50% intensity happy (vs. neutral) faces. gPPI analyses revealed that MDD adolescents showed significantly lower right DLPFC functional connectivity with the ventrolateral PFC (VLPFC) compared to HC to all happy faces. LIMITATIONS: The current study is limited by the smaller number of healthy offspring at risk for MDD compared to BD. CONCLUSIONS: Because Mood-risk adolescents were healthy at the time of the scan, elevated DLPFC and lowered ventral striatal activity in Mood-risk adolescents may be associated with risk or resiliency. In contrast, altered DLPFC-VLPFC functional connectivity in MDD adolescents may be associated with depressed mood state. Such alterations may affect social-affective development and progression to a mood disorder in Mood-risk adolescents. Future longitudinal follow-up studies are needed to directly answer this research question.
Authors: Kezia Lange; Leanne M Williams; Andrew W Young; Edward T Bullmore; Michael J Brammer; Steven C R Williams; Jeffrey A Gray; Mary L Phillips Journal: Biol Psychiatry Date: 2003-02-01 Impact factor: 13.382
Authors: Steven D Hollon; Richard C Shelton; Stephen Wisniewski; Diane Warden; Melanie M Biggs; Edward S Friedman; Mustafa Husain; David J Kupfer; Andrew A Nierenberg; Timothy J Petersen; Kathy Shores-Wilson; A John Rush Journal: J Psychiatr Res Date: 2005-10-21 Impact factor: 4.791
Authors: Christopher S Monk; Rachel G Klein; Eva H Telzer; Elizabeth A Schroth; Salvatore Mannuzza; John L Moulton; Mary Guardino; Carrie L Masten; Erin B McClure-Tone; Stephen Fromm; R James Blair; Daniel S Pine; Monique Ernst Journal: Am J Psychiatry Date: 2007-11-06 Impact factor: 18.112
Authors: Tiffany C Ho; Guang Yang; Jing Wu; Pete Cassey; Scott D Brown; Napoleon Hoang; Melanie Chan; Colm G Connolly; Eva Henje-Blom; Larissa G Duncan; Margaret A Chesney; Martin P Paulus; Jeffrey E Max; Ronak Patel; Alan N Simmons; Tony T Yang Journal: J Affect Disord Date: 2013-10-25 Impact factor: 4.839
Authors: Rebecca Kerestes; Christopher G Davey; Katerina Stephanou; Sarah Whittle; Ben J Harrison Journal: Neuroimage Clin Date: 2013-12-11 Impact factor: 4.881
Authors: Tiffany C Ho; Giana I Teresi; Amar Ojha; Johanna C Walker; Jaclyn S Kirshenbaum; Manpreet K Singh; Ian H Gotlib Journal: J Affect Disord Date: 2020-09-14 Impact factor: 6.533