| Literature DB >> 26722435 |
Yingchi Yang1, Jun Cai1, Jie Yin1, Dong Wang1, Zhigang Bai1, Jun Zhang1, Kangli Wang1, Guanzhen Yu2, Zhongtao Zhang1.
Abstract
Inorganic pyrophosphatase (PPA1) is an enzyme which has been found to be upregulated in various tumors, yet its profile in gastrointestinal cancers has not systemically investigated. In present study, gastrointestinal tissue microarrays were used to evaluate PPA1 expression and the association of PPA1 expression with clinical outcomes was determined for patients with gastric cancer by immunohistochemistry. Overexpression of PPA1 was observed in cancers of the esophagus, stomach, and pancreaticobiliary system. PPA1 was overexpressed in 143 cases (51.3%) of the 279 primary gastric tumors and was associated with larger size (> 3 cm), nodal metastasis and advanced clinical staging (P < 0.05). Moreover, survival analysis demonstrated that PPA1 expression was significantly correlated reduced overall of patients with gastric cancer. Therefore, PPA1 may serve as a potential biomarker of poor prognosis in patients with gastric cancer.Entities:
Keywords: Gastric cancer; PPA1; metastasis
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Year: 2015 PMID： 26722435 PMCID： PMC4680380
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625