Kohta Fujiwara1, Miho Yasuda2, Toshiharu Ninomiya3, Jun Hata3, Sawako Hashimoto4, Takeshi Yoshitomi5, Yutaka Kiyohara6, Tatsuro Ishibashi2. 1. Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Department of Ophthalmology, Graduate School. 2. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 3. Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 4Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 5Department of Medicine and Clinical Science, Gr. 4. Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 5. Department of Ophthalmology, Graduate School of Medical Sciences, Akita University, Akita, Japan. 6. Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Abstract
PURPOSE: To investigate association of the homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate index of insulin resistance, with IOP in a general Japanese population. METHODS: In 2007, a total of 3119 Japanese community-dwellers, aged 40 years or older, underwent eye examinations, including IOP measurement with a noncontact tonometer. Of these, 2254 residents participated in this study. Fasting serum glucose and plasma insulin were measured to determine the HOMA-IR. The association of HOMA-IR with IOP was assessed using a linear regression model, adjusted for age and possible risk factors that can elevate IOP. RESULTS: The mean IOP ± SD was 13.7 ± 2.7 mm Hg in the right eye and 13.6 ± 2.7 mm Hg in the left eye. After adjusting for age, sex, systolic blood pressure, diabetes, total cholesterol, high-density lipoprotein cholesterol, body mass index, waist circumference, smoking habits, alcohol intake, and regular exercise, increased HOMA-IR levels were significantly associated with increasing IOP (P < 0.05). In the subgroup analyses based on the presence or absence of possible confounding risk factors, there was no evidence of heterogeneity between all subgroups (P for heterogeneity > 0.08). CONCLUSIONS: The HOMA-IR is independently associated with elevated IOP levels after adjustment for confounding factors.
PURPOSE: To investigate association of the homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate index of insulin resistance, with IOP in a general Japanese population. METHODS: In 2007, a total of 3119 Japanese community-dwellers, aged 40 years or older, underwent eye examinations, including IOP measurement with a noncontact tonometer. Of these, 2254 residents participated in this study. Fasting serum glucose and plasma insulin were measured to determine the HOMA-IR. The association of HOMA-IR with IOP was assessed using a linear regression model, adjusted for age and possible risk factors that can elevate IOP. RESULTS: The mean IOP ± SD was 13.7 ± 2.7 mm Hg in the right eye and 13.6 ± 2.7 mm Hg in the left eye. After adjusting for age, sex, systolic blood pressure, diabetes, total cholesterol, high-density lipoprotein cholesterol, body mass index, waist circumference, smoking habits, alcohol intake, and regular exercise, increased HOMA-IR levels were significantly associated with increasing IOP (P < 0.05). In the subgroup analyses based on the presence or absence of possible confounding risk factors, there was no evidence of heterogeneity between all subgroups (P for heterogeneity > 0.08). CONCLUSIONS: The HOMA-IR is independently associated with elevated IOP levels after adjustment for confounding factors.
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