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Literature DB >> 26719842

CANCER STEM CELLS IN OSTEOSARCOMA.

Abstract

Osteosarcoma is the most common type of bone cancer and the second leading cause of cancer-related deaths in pediatric patients. Despite conventional treatments such as surgery and chemotherapy, long-term survival rates for patients diagnosed with osteosarcoma have not improved over the last 30 years, likely due to drug-resistant metastasis and disease recurrence. An emerging concept in cancer research is that within a heterogeneous tumor there is a small subset of cells called "cancer stem cells" that are responsible for drug resistance, tumor recurrence and metastasis. This brief review summarizes our current knowledge about cancer stem cells in osteosarcoma, including their potential as a new target for osteosarcoma treatment.

Entities: Disease Gene Species

Year: 2013 PMID： 26719842 PMCID： PMC4692277

Source DB: PubMed Journal: Case Orthop J ISSN： 2324-8882

40 in total

1. Osteosarcoma.

Authors: Richard Gorlick; Chand Khanna
Journal: J Bone Miner Res Date: 2010-04 Impact factor: 6.741

2. Eyes wide open: a critical review of sphere-formation as an assay for stem cells.

Authors: Erika Pastrana; Violeta Silva-Vargas; Fiona Doetsch
Journal: Cell Stem Cell Date: 2011-05-06 Impact factor: 24.633

Review 3. Osteosarcoma: basic science and clinical implications.

Authors: James B Hayden; Bang H Hoang
Journal: Orthop Clin North Am Date: 2006-01 Impact factor: 2.472

Review 4. Current treatment of osteosarcoma.

Authors: W S Ferguson; A M Goorin
Journal: Cancer Invest Date: 2001 Impact factor: 2.176

Review 5. Primary bone osteosarcoma in the pediatric age: state of the art.

Authors: Alessandra Longhi; Costantino Errani; Massimiliano De Paolis; Mario Mercuri; Gaetano Bacci
Journal: Cancer Treat Rev Date: 2006-07-24 Impact factor: 12.111

6. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage.

Authors: Seth D Berman; Eliezer Calo; Allison S Landman; Paul S Danielian; Emily S Miller; Julie C West; Borel Djouedjong Fonhoue; Alicia Caron; Roderick Bronson; Mary L Bouxsein; Siddhartha Mukherjee; Jacqueline A Lees
Journal: Proc Natl Acad Sci U S A Date: 2008-08-12 Impact factor: 11.205

Review 7. Osteosarcoma.

Authors: Patrick J Messerschmitt; Ryan M Garcia; Fadi W Abdul-Karim; Edward M Greenfield; Patrick J Getty
Journal: J Am Acad Orthop Surg Date: 2009-08 Impact factor: 3.020

CANCER STEM CELLS IN OSTEOSARCOMA.

1. Osteosarcoma.

2. Eyes wide open: a critical review of sphere-formation as an assay for stem cells.

Review 3. Osteosarcoma: basic science and clinical implications.

Review 4. Current treatment of osteosarcoma.

Review 5. Primary bone osteosarcoma in the pediatric age: state of the art.

6. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage.

Review 7. Osteosarcoma.

8. Targeting the osteosarcoma cancer stem cell.

9. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling.

10. Human osteosarcoma CD49f(-)CD133(+) cells: impaired in osteogenic fate while gain of tumorigenicity.

1. The Na+/K+ ATPase Inhibitor Ouabain Attenuates Stemness and Chemoresistance of Osteosarcoma Cells.

2. Blocking the PD-1/PD-L1 axis enhanced cisplatin chemotherapy in osteosarcoma in vitro and in vivo.