Literature DB >> 26719251

Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets.

Raffael Nachbagauer1, Matthew S Miller2, Rong Hai3, Alex B Ryder4, John K Rose4, Peter Palese5, Adolfo García-Sastre6, Florian Krammer7, Randy A Albrecht8.   

Abstract

We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26719251      PMCID： PMC4810634          DOI： 10.1128/JVI.02481-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets.

Authors:  Florian Krammer; Rong Hai; Mark Yondola; Gene S Tan; Victor H Leyva-Grado; Alex B Ryder; Matthew S Miller; John K Rose; Peter Palese; Adolfo García-Sastre; Randy A Albrecht
Journal:  J Virol       Date:  2014-01-08       Impact factor: 5.103

2.  Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo.

Authors:  David J DiLillo; Gene S Tan; Peter Palese; Jeffrey V Ravetch
Journal:  Nat Med       Date:  2014-01-12       Impact factor: 53.440

Review 3.  To dream the impossible dream: universal influenza vaccination.

Authors:  Jonathan W Yewdell
Journal:  Curr Opin Virol       Date:  2013-07-05       Impact factor: 7.090

4.  Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection.

Authors:  Vamsee V A Mallajosyula; Michael Citron; Francesca Ferrara; Xianghan Lu; Cheryl Callahan; Gwendolyn J Heidecker; Siddhartha P Sarma; Jessica A Flynn; Nigel J Temperton; Xiaoping Liang; Raghavan Varadarajan
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-09       Impact factor: 11.205

Review 5.  Towards a universal influenza vaccine: volunteer virus challenge studies in quarantine to speed the development and subsequent licensing.

Authors:  John S Oxford
Journal:  Br J Clin Pharmacol       Date:  2013-08       Impact factor: 4.335

Review 6.  The prospects and challenges of universal vaccines for influenza.

Authors:  Kanta Subbarao; Yumiko Matsuoka
Journal:  Trends Microbiol       Date:  2013-05-17       Impact factor: 17.079

7.  Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection.

Authors:  Hadi M Yassine; Jeffrey C Boyington; Patrick M McTamney; Chih-Jen Wei; Masaru Kanekiyo; Wing-Pui Kong; John R Gallagher; Lingshu Wang; Yi Zhang; M Gordon Joyce; Daniel Lingwood; Syed M Moin; Hanne Andersen; Yoshinobu Okuno; Srinivas S Rao; Audray K Harris; Peter D Kwong; John R Mascola; Gary J Nabel; Barney S Graham
Journal:  Nat Med       Date:  2015-08-24       Impact factor: 53.440

8.  Vaccine-induced anti-HA2 antibodies promote virus fusion and enhance influenza virus respiratory disease.

Authors:  Surender Khurana; Crystal L Loving; Jody Manischewitz; Lisa R King; Phillip C Gauger; Jamie Henningson; Amy L Vincent; Hana Golding
Journal:  Sci Transl Med       Date:  2013-08-28       Impact factor: 17.956

9.  Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs.

Authors:  Christopher W Seibert; Saad Rahmat; Jens C Krause; Dirk Eggink; Randy A Albrecht; Peter H Goff; Florian Krammer; J Andrew Duty; Nicole M Bouvier; Adolfo García-Sastre; Peter Palese
Journal:  J Virol       Date:  2013-05-22       Impact factor: 5.103

Review 10.  Influenza virus hemagglutinin stalk-based antibodies and vaccines.

Authors:  Florian Krammer; Peter Palese
Journal:  Curr Opin Virol       Date:  2013-08-24       Impact factor: 7.090
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  41 in total

1.  Protection by universal influenza vaccine is mediated by memory CD4 T cells.

Authors:  Sophie A Valkenburg; Olive T W Li; Athena Li; Maireid Bull; Thomas A Waldmann; Liyanage P Perera; Malik Peiris; Leo L M Poon
Journal:  Vaccine       Date:  2018-06-07       Impact factor: 3.641

2.  Dynamic Perspectives on the Search for a Universal Influenza Vaccine.

Authors:  Chadi M Saad-Roy; Adrian B McDermott; Bryan T Grenfell
Journal:  J Infect Dis       Date:  2019-04-08       Impact factor: 5.226

Review 3.  Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Immunogenetic Considerations Underlying B-Cell Biology in the Development of a Pan-Subtype Influenza A Vaccine Targeting the Hemagglutinin Stem.

Authors:  Sarah F Andrews; Barney S Graham; John R Mascola; Adrian B McDermott
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-07-02       Impact factor: 10.005

4.  Universal Influenza Virus Vaccines That Target the Conserved Hemagglutinin Stalk and Conserved Sites in the Head Domain.

Authors:  Florian Krammer; Peter Palese
Journal:  J Infect Dis       Date:  2019-04-08       Impact factor: 5.226

5.  Chimeric Hemagglutinin-Based Influenza Virus Vaccines Induce Protective Stalk-Specific Humoral Immunity and Cellular Responses in Mice.

Authors:  Angela Choi; Badiaa Bouzya; Klaus-Daniel Cortés Franco; Daniel Stadlbauer; Arvind Rajabhathor; Ronan N Rouxel; Roland Mainil; Marie Van der Wielen; Peter Palese; Adolfo García-Sastre; Bruce L Innis; Florian Krammer; Michael Schotsaert; Corey P Mallett; Raffael Nachbagauer
Journal:  Immunohorizons       Date:  2019-04-01

6.  Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model.

Authors:  Megan E Ermler; Ericka Kirkpatrick; Weina Sun; Rong Hai; Fatima Amanat; Veronika Chromikova; Peter Palese; Florian Krammer
Journal:  J Virol       Date:  2017-05-26       Impact factor: 5.103

Review 7.  From Original Antigenic Sin to the Universal Influenza Virus Vaccine.

Authors:  Carole Henry; Anna-Karin E Palm; Florian Krammer; Patrick C Wilson
Journal:  Trends Immunol       Date:  2017-08-31       Impact factor: 16.687

Review 8.  Universal influenza virus vaccines and therapeutic antibodies.

Authors:  R Nachbagauer; F Krammer
Journal:  Clin Microbiol Infect       Date:  2017-02-12       Impact factor: 8.067

Review 9.  Novel universal influenza virus vaccine approaches.

Authors:  Florian Krammer
Journal:  Curr Opin Virol       Date:  2016-02-27       Impact factor: 7.090

10.  TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines.

Authors:  Irene Rivero-Calle; Jose Gómez-Rial; Louis Bont; Bradford D Gessner; Melvin Kohn; Ron Dagan; Daniel C Payne; Laia Bruni; Andrew J Pollard; Adolfo García-Sastre; Denise L Faustman; Albert Osterhaus; Robb Butler; Francisco Giménez Sánchez; Francisco Álvarez; Myrsini Kaforou; Xabier Bello; Federico Martinón-Torres
Journal:  Hum Vaccin Immunother       Date:  2020-08-05       Impact factor: 3.452
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