Amira El Merhie1, Laurent Navarro1, Xavier Delavenne2, Lara Leclerc3, Jérémie Pourchez1. 1. Ecole Nationale Supérieure des Mines, CIS-EMSE, Sainbiose UMR INSERM 1059, SFR FED 4166 - IFRESIS, F-42023, Saint-Etienne, France. 2. Laboratoire de Pharmacologie - Toxicologie, Sainbiose UMR INSERM 1059, CHU de Saint-Etienne, F-42055, Saint-Etienne, France. 3. Ecole Nationale Supérieure des Mines, CIS-EMSE, Sainbiose UMR INSERM 1059, SFR FED 4166 - IFRESIS, F-42023, Saint-Etienne, France. Leclerc@emse.fr.
Abstract
PURPOSE: Enhancement of intranasal sinus deposition involves nebulization of a drug superimposed by an acoustic airflow. We investigated the impact of fixed frequency versus frequency sweep acoustic airflow on the improvement of aerosolized drug penetration into maxillary sinuses. METHODS: Fixed frequency and frequency sweep acoustic airflow were generated using a nebulizing system of variable frequency. The effect of sweep cycle and intensity variation was studied on the intranasal sinus deposition. We used a nasal replica created from CT scans using 3D printing. Sodium fluoride and gentamicin were chosen as markers. RESULTS: Studies performed using fixed frequency acoustic airflow showed that each of maxillary sinuses of the nasal replica required specific frequency for the optimal aerosol deposition. Intranasal sinus drug deposition experiments under the effect of the frequency sweep acoustic airflow showed an optimal aerosol deposition into both maxillary sinus of the nasal replica. Studies on the effect of the duration of the sweep cycle showed that the shorter the cycle the better the deposition. CONCLUSIONS: We demonstrate the benefit of frequency sweep acoustic airflow on drug deposition into maxillary sinuses. However further in vivo studies have to be conducted since delivery rates cannot be obviously determined from a nasal replica.
PURPOSE: Enhancement of intranasal sinus deposition involves nebulization of a drug superimposed by an acoustic airflow. We investigated the impact of fixed frequency versus frequency sweep acoustic airflow on the improvement of aerosolized drug penetration into maxillary sinuses. METHODS: Fixed frequency and frequency sweep acoustic airflow were generated using a nebulizing system of variable frequency. The effect of sweep cycle and intensity variation was studied on the intranasal sinus deposition. We used a nasal replica created from CT scans using 3D printing. Sodium fluoride and gentamicin were chosen as markers. RESULTS: Studies performed using fixed frequency acoustic airflow showed that each of maxillary sinuses of the nasal replica required specific frequency for the optimal aerosol deposition. Intranasal sinus drug deposition experiments under the effect of the frequency sweep acoustic airflow showed an optimal aerosol deposition into both maxillary sinus of the nasal replica. Studies on the effect of the duration of the sweep cycle showed that the shorter the cycle the better the deposition. CONCLUSIONS: We demonstrate the benefit of frequency sweep acoustic airflow on drug deposition into maxillary sinuses. However further in vivo studies have to be conducted since delivery rates cannot be obviously determined from a nasal replica.
Authors: Marc Durand; Jérémie Pourchez; Bruno Louis; Jean François Pouget; Daniel Isabey; André Coste; Jean Michel Prades; Philippe Rusch; Michèle Cottier Journal: Rhinology Date: 2011-03 Impact factor: 3.681
Authors: B L Laube; H M Janssens; F H C de Jongh; S G Devadason; R Dhand; P Diot; M L Everard; I Horvath; P Navalesi; T Voshaar; H Chrystyn Journal: Eur Respir J Date: 2011-02-10 Impact factor: 16.671
Authors: Winfried Möller; Uwe Schuschnig; Gülnaz Celik; Wolfgang Münzing; Peter Bartenstein; Karl Häussinger; Wolfgang G Kreyling; Martin Knoch; Martin Canis; Sven Becker Journal: PLoS One Date: 2013-09-11 Impact factor: 3.240