Lara Leclerc1, Amira El Merhie2, Laurent Navarro2, Nathalie Prévôt3, Marc Durand4, Jérémie Pourchez2. 1. Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624-LINA, SFR FED 4166-IFRESIS, 10 rue de la Marandière-42270 Saint-Priest en Jarez, F-42023 Saint-Etienne, France. Electronic address: leclerc@emse.fr. 2. Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624-LINA, SFR FED 4166-IFRESIS, 10 rue de la Marandière-42270 Saint-Priest en Jarez, F-42023 Saint-Etienne, France. 3. University of Lyon, Jean Monnet University, EA 4624-LINA, SFR FED 4166-IFRESIS, F-42023 Saint-Etienne, France; University Hospital CHU, Nuclear Medicine Department, Saint-Etienne, France. 4. University of Lyon, Jean Monnet University, EA 4624-LINA, SFR FED 4166-IFRESIS, F-42023 Saint-Etienne, France; Centre Hospitalier Emile Roux, ENT Department, F-43012 Le Puy en Velay, France.
Abstract
AIM: We investigated the impact of vibrating acoustic airflow, the high frequency (f≥100 Hz) and the low frequency (f≤45 Hz) sound waves, on the enhancement of intrasinus drug deposition. METHODS: (81m)Kr-gas ventilation study was performed in a plastinated human cast with and without the addition of vibrating acoustic airflow. Similarly, intrasinus drug deposition in a nasal replica using gentamicin as a marker was studied with and without the superposition of different modes of acoustic airflow. RESULTS: Ventilation experiments demonstrate that no sinus ventilation was observed without acoustic airflow although sinus ventilation occurred whatever the modes of acoustic airflow applied. Intrasinus drug deposition experiments showed that the high frequency acoustic airflow led to 4-fold increase in gentamicin deposition into the left maxillary sinus and to 2-fold deposition increase into the right maxillary sinus. Besides, the low frequency acoustic airflow demonstrated a significant increase of 4-fold and 2-fold in the right and left maxillary sinuses, respectively. CONCLUSION: We demonstrated the benefit of different modes of vibrating acoustic airflow for maxillary sinus ventilation and intrasinus drug deposition. The degree of gentamicin deposition varies as a function of frequency of the vibrating acoustic airflow and the geometry of the ostia.
AIM: We investigated the impact of vibrating acoustic airflow, the high frequency (f≥100 Hz) and the low frequency (f≤45 Hz) sound waves, on the enhancement of intrasinus drug deposition. METHODS: (81m)Kr-gas ventilation study was performed in a plastinated human cast with and without the addition of vibrating acoustic airflow. Similarly, intrasinus drug deposition in a nasal replica using gentamicin as a marker was studied with and without the superposition of different modes of acoustic airflow. RESULTS: Ventilation experiments demonstrate that no sinus ventilation was observed without acoustic airflow although sinus ventilation occurred whatever the modes of acoustic airflow applied. Intrasinus drug deposition experiments showed that the high frequency acoustic airflow led to 4-fold increase in gentamicin deposition into the left maxillary sinus and to 2-fold deposition increase into the right maxillary sinus. Besides, the low frequency acoustic airflow demonstrated a significant increase of 4-fold and 2-fold in the right and left maxillary sinuses, respectively. CONCLUSION: We demonstrated the benefit of different modes of vibrating acoustic airflow for maxillary sinus ventilation and intrasinus drug deposition. The degree of gentamicin deposition varies as a function of frequency of the vibrating acoustic airflow and the geometry of the ostia.