A Leclercq1, B Labeille2, J-L Perrot1, P Vercherin3, F Cambazard1. 1. Dermatology Department, hôpital Nord, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France. 2. Dermatology Department, hôpital Nord, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France. Electronic address: bruno.labeille@chu-st-etienne.fr. 3. Department of Public Health and Medical Information, hôpital Nord, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France.
Abstract
INTRODUCTION:Leg ulcers are a common condition. There have been very few studies of combined therapy involving VAC (vacuum-assisted closure) and skin graft. METHODS: We performed a randomized controlled trial of VAC therapy vs. hydrocolloid dressings over 5 days following autologous grafting on chronic leg ulcers. The primary objective was to assess the difference in success (defined as a reduction in wound area of at least 50% at 1 month) between the two dressing methods. Forty-six patients with ulcers present for over one month were included. Following a 7-day hospitalization period, follow-up was performed for 3 months on an outpatient basis. RESULTS: Our study does not demonstrate a statistically significant difference, with a 45.8% success rate in the VAC group vs. 40.9% in the conventional dressing group (P=0.73). In the venous ulcer group, the success rate was 57.9% for VAC vs. 40% for conventional dressings (P=0.3). The difference in favor of VAC in this group was not statistically significant, most likely due to an insufficient number of patients studied. CONCLUSION: Our study does not demonstrate superiority of VAC associated with skin graft over conventional dressings. We observed more complications with VAC (40%) than with conventional dressings (23%) (P=0.06).
RCT Entities:
INTRODUCTION:Leg ulcers are a common condition. There have been very few studies of combined therapy involving VAC (vacuum-assisted closure) and skin graft. METHODS: We performed a randomized controlled trial of VAC therapy vs. hydrocolloid dressings over 5 days following autologous grafting on chronic leg ulcers. The primary objective was to assess the difference in success (defined as a reduction in wound area of at least 50% at 1 month) between the two dressing methods. Forty-six patients with ulcers present for over one month were included. Following a 7-day hospitalization period, follow-up was performed for 3 months on an outpatient basis. RESULTS: Our study does not demonstrate a statistically significant difference, with a 45.8% success rate in the VAC group vs. 40.9% in the conventional dressing group (P=0.73). In the venous ulcer group, the success rate was 57.9% for VAC vs. 40% for conventional dressings (P=0.3). The difference in favor of VAC in this group was not statistically significant, most likely due to an insufficient number of patients studied. CONCLUSION: Our study does not demonstrate superiority of VAC associated with skin graft over conventional dressings. We observed more complications with VAC (40%) than with conventional dressings (23%) (P=0.06).
Authors: Ravul Jindal; D B Dekiwadia; Pinjala Rama Krishna; Ajay K Khanna; Malay D Patel; Shoaib Padaria; Roy Varghese Journal: Indian J Surg Date: 2018-01-27 Impact factor: 0.656
Authors: Yvonne Zens; Michael Barth; Heiner C Bucher; Katrin Dreck; Moritz Felsch; Wolfram Groß; Thomas Jaschinski; Heike Kölsch; Mandy Kromp; Inga Overesch; Stefan Sauerland; Sven Gregor Journal: Syst Rev Date: 2020-10-10