Shixin Chang1, Jingwei Zhang2,3, Tian Liu2, Apostolos John Tsiouris2, Jian Shou4, Thanh Nguyen2, Dana Leifer5, Yi Wang2,3, Ilhami Kovanlikaya2. 1. Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese & Western Medicine, Shanghai, China. 2. Department of Radiology, Weill Cornell Medical College, New York, New York, USA. 3. Department of Biomedical Engineering, Cornell University, New York, New York, USA. 4. Department of Surgery, Weill Cornell Medical College, New York, New York, USA. 5. Department of Neurology, Weill Cornell Medical College, New York, New York, USA.
Abstract
PURPOSE: To investigate the magnetic susceptibility of intracerebral hemorrhages (ICH) at various stages by applying quantitative susceptibility mapping (QSM). MATERIALS AND METHODS: Blood susceptibility was measured serially using QSM after venous blood withdrawal from healthy subjects. Forty-two patients who provided written consent were recruited in this Institutional Review Board-approved study. Gradient echo magnetic resonance imaging (MRI) data of the 42 patients (17 females; 64 ± 12 years) with ICH were processed with QSM. The susceptibilities of various blood products within hematomas were measured on QSM. RESULTS: Blood susceptibility continually increased and reached a plateau 96 hours after venous blood withdrawal. Hematomas at all stages were consistently hyperintense on QSM. Susceptibility was 0.57 ± 0.48, 1.30 ± 0.33, 1.14 ± 0.46, 0.40 ± 0.13, and 0.71 ± 0.31 ppm for hyperacute, acute, early subacute, late subacute, and chronic stages of hematomas, respectively. The susceptibility decrease from early subacute (1.14 ppm) to late subacute (0.4 ppm) was significant (P < 0.01). CONCLUSION: QSM reveals positive susceptibility in hyperacute hematomas, indicating that even at their hyperacute stage, deoxyhemoglobin may exist throughout the hematoma volume, not just at its rim, as seen on conventional T2* imaging. QSM also reveals a reduction of susceptibility from early subacute to late subacute ICH, suggesting that methemoglobin concentration decreases at the late subacute stage. J. Magn. Reson. Imaging 2016;44:420-425.
PURPOSE: To investigate the magnetic susceptibility of intracerebral hemorrhages (ICH) at various stages by applying quantitative susceptibility mapping (QSM). MATERIALS AND METHODS: Blood susceptibility was measured serially using QSM after venous blood withdrawal from healthy subjects. Forty-two patients who provided written consent were recruited in this Institutional Review Board-approved study. Gradient echo magnetic resonance imaging (MRI) data of the 42 patients (17 females; 64 ± 12 years) with ICH were processed with QSM. The susceptibilities of various blood products within hematomas were measured on QSM. RESULTS: Blood susceptibility continually increased and reached a plateau 96 hours after venous blood withdrawal. Hematomas at all stages were consistently hyperintense on QSM. Susceptibility was 0.57 ± 0.48, 1.30 ± 0.33, 1.14 ± 0.46, 0.40 ± 0.13, and 0.71 ± 0.31 ppm for hyperacute, acute, early subacute, late subacute, and chronic stages of hematomas, respectively. The susceptibility decrease from early subacute (1.14 ppm) to late subacute (0.4 ppm) was significant (P < 0.01). CONCLUSION: QSM reveals positive susceptibility in hyperacute hematomas, indicating that even at their hyperacute stage, deoxyhemoglobin may exist throughout the hematoma volume, not just at its rim, as seen on conventional T2* imaging. QSM also reveals a reduction of susceptibility from early subacute to late subacute ICH, suggesting that methemoglobin concentration decreases at the late subacute stage. J. Magn. Reson. Imaging 2016;44:420-425.
Authors: Tian Liu; Jing Liu; Ludovic de Rochefort; Pascal Spincemaille; Ildar Khalidov; James Robert Ledoux; Yi Wang Journal: Magn Reson Med Date: 2011-04-04 Impact factor: 4.668
Authors: M Azuma; K Maekawa; A Yamashita; K Yokogami; M Enzaki; Z A Khant; H Takeshima; Y Asada; Y Wang; T Hirai Journal: AJNR Am J Neuroradiol Date: 2019-12-26 Impact factor: 3.825
Authors: Yi Wang; Pascal Spincemaille; Zhe Liu; Alexey Dimov; Kofi Deh; Jianqi Li; Yan Zhang; Yihao Yao; Kelly M Gillen; Alan H Wilman; Ajay Gupta; Apostolos John Tsiouris; Ilhami Kovanlikaya; Gloria Chia-Yi Chiang; Jonathan W Weinsaft; Lawrence Tanenbaum; Weiwei Chen; Wenzhen Zhu; Shixin Chang; Min Lou; Brian H Kopell; Michael G Kaplitt; David Devos; Toshinori Hirai; Xuemei Huang; Yukunori Korogi; Alexander Shtilbans; Geon-Ho Jahng; Daniel Pelletier; Susan A Gauthier; David Pitt; Ashley I Bush; Gary M Brittenham; Martin R Prince Journal: J Magn Reson Imaging Date: 2017-03-10 Impact factor: 4.813
Authors: Kofi Deh; Keigo Kawaji; Marjolein Bulk; Louise Van Der Weerd; Emelie Lind; Pascal Spincemaille; Kelly McCabe Gillen; Johan Van Auderkerke; Yi Wang; Thanh D Nguyen Journal: Magn Reson Med Date: 2018-10-04 Impact factor: 4.668
Authors: Arnold Tóth; Zoltán Berente; Péter Bogner; Bálint Környei; Bendegúz Balogh; Endre Czeiter; Krisztina Amrein; Tamás Dóczi; András Büki; Attila Schwarcz Journal: J Neurotrauma Date: 2019-01-08 Impact factor: 5.269