Literature DB >> 2671700

Endogenous DNA damage as related to cancer and aging.

B N Ames1.   

Abstract

The endogenous background level of oxidant-induced DNA damage in vivo has been assayed by measuring 8-hydroxydeoxyguanosine (oh8dG), thymine glycol and thymidine glycol in urine and oh8dG in DNA. The level of oxidative DNA damage as measured by oh8dG in normal rat liver is shown to be extensive (1/130,000 bases in nuclear DNA and 1/8000 bases in mitochondrial DNA), especially in mtDNA. The methylation adduct 7-methylguanine (m7G) has also been found. m7G is one of about 5 adducts found on methylating DNA, and oh8dG is one of about 20 adducts found on oxidizing DNA, e.g., by radiation. We also discuss 3 hitherto unrecognized antioxidants in man.

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Year:  1989        PMID： 2671700     DOI： 10.1016/0027-5107(89)90196-6

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  43 in total

1.  Clusters of S1 nuclease-hypersensitive sites induced in vivo by DNA damage.

Authors:  J Legault; A Tremblay; D Ramotar; M E Mirault
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

2.  DNA helix: the importance of being GC-rich.

Authors:  Alexander E Vinogradov
Journal:  Nucleic Acids Res       Date:  2003-04-01       Impact factor: 16.971

3.  Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage.

Authors:  Rui Yu; Yongquan Lai; Hadley J Hartwell; Benjamin C Moeller; Melanie Doyle-Eisele; Dean Kracko; Wanda M Bodnar; Thomas B Starr; James A Swenberg
Journal:  Toxicol Sci       Date:  2015-04-21       Impact factor: 4.849

4.  Effects of formic acid hydrolysis on the quantitative analysis of radiation-induced DNA base damage products assayed by gas chromatography/mass spectrometry.

Authors:  S G Swarts; G S Smith; L Miao; K T Wheeler
Journal:  Radiat Environ Biophys       Date:  1996-02       Impact factor: 1.925

5.  Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA.

Authors:  W J Driggers; G P Holmquist; S P LeDoux; G L Wilson
Journal:  Nucleic Acids Res       Date:  1997-11-01       Impact factor: 16.971

6.  Development of immunoblotting techniques for DNA radical detection.

Authors:  Fiona A Summers; Ronald P Mason; Marilyn Ehrenshaft
Journal:  Free Radic Biol Med       Date:  2012-11-07       Impact factor: 7.376

7.  Serum Metabolomic Profiling of All-Cause Mortality: A Prospective Analysis in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study Cohort.

Authors:  Jiaqi Huang; Stephanie J Weinstein; Steven C Moore; Andriy Derkach; Xing Hua; Linda M Liao; Fangyi Gu; Alison M Mondul; Joshua N Sampson; Demetrius Albanes
Journal:  Am J Epidemiol       Date:  2018-08-01       Impact factor: 4.897

8.  Increased urinary excretion of 8-hydroxydeoxyguanosine in engine room personnel exposed to polycyclic aromatic hydrocarbons.

Authors:  R Nilsson; R Nordlinder; B E Moen; S Øvrebø; K Bleie; A H Skorve; B E Hollund; C Tagesson
Journal:  Occup Environ Med       Date:  2004-08       Impact factor: 4.402

9.  N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

Authors:  R S Cha; W G Thilly; H Zarbl
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

10.  No association between mitochondrial DNA copy number and colorectal adenomas.

Authors:  Bharat Thyagarajan; Weihua Guan; Veronika Fedirko; Helene Barcelo; Huakang Tu; Myron Gross; Michael Goodman; Roberd M Bostick
Journal:  Mol Carcinog       Date:  2015-08-10       Impact factor: 4.784
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