Christine M Freitag1, Katrin Jensen2, Leyla Elsuni1, Michael Sachse1, Beate Herpertz-Dahlmann3, Martin Schulte-Rüther3, Susann Hänig4, Alexander von Gontard4, Luise Poustka5,6, Tanja Schad-Hansjosten5, Christina Wenzl7, Judith Sinzig7,8, Regina Taurines9, Julia Geißler9, Meinhard Kieser2, Hannah Cholemkery1. 1. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany. 2. Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany. 3. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital RWTH Aachen, Aachen, Germany. 4. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Saarland University Hospital Homburg, Saarbrücken, Germany. 5. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. 6. Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria. 7. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Köln, Cologne, Germany. 8. Department of Child and Adolescent Psychiatry, LVR Klinik Bonn, Bonn, Germany. 9. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany.
Abstract
BACKGROUND: Group-based psychotherapy in Autism Spectrum Disorder (ASD) has predominantly been studied in the United States by small studies in school-aged children without long-term follow-up. We report results of a large, confirmatory, multicentre randomized-controlled phase-III trial in children and adolescents studying the ASD specific, manualized group-based cognitive behavioural SOSTA-FRA approach. METHODS:High-functioning ASD individuals aged 8-19 years old were randomized to 12 sessions SOSTA-FRA or treatment as usual. Primary outcomes were change in total raw score of the parent-rated Social Responsiveness Scale (pSRS) between baseline (T2) and end of intervention (T4), and between T2 and 3 months after end of intervention (T5). TRIAL REGISTRATION: ISRCTN94863788. RESULTS: Between 20/5/2010 and 14/2/2013, n = 320 ASD patients were screened, n = 228 patients were randomized, and N = 209 analysed. Mean pSRS difference between groups at T4 was -6.5 (95% CI -11.6 to - 1.4; p = .013), and at T5 -6.4 (-11.5 to -1.3, p = .015). Pre-treatment SRS and IQ were positively associated with stronger improvement at T4 and T5. CONCLUSIONS: Short-term ASD-specific add-on group-based psychotherapy has shown postintervention efficacy with regard to parent-rated social responsiveness predominantly in male high-functioning children and adolescents with ASD. Future studies should implement blinded standardized observational measures of peer-related social interaction.
RCT Entities:
BACKGROUND: Group-based psychotherapy in Autism Spectrum Disorder (ASD) has predominantly been studied in the United States by small studies in school-aged children without long-term follow-up. We report results of a large, confirmatory, multicentre randomized-controlled phase-III trial in children and adolescents studying the ASD specific, manualized group-based cognitive behavioural SOSTA-FRA approach. METHODS: High-functioning ASD individuals aged 8-19 years old were randomized to 12 sessions SOSTA-FRA or treatment as usual. Primary outcomes were change in total raw score of the parent-rated Social Responsiveness Scale (pSRS) between baseline (T2) and end of intervention (T4), and between T2 and 3 months after end of intervention (T5). TRIAL REGISTRATION: ISRCTN94863788. RESULTS: Between 20/5/2010 and 14/2/2013, n = 320 ASDpatients were screened, n = 228 patients were randomized, and N = 209 analysed. Mean pSRS difference between groups at T4 was -6.5 (95% CI -11.6 to - 1.4; p = .013), and at T5 -6.4 (-11.5 to -1.3, p = .015). Pre-treatment SRS and IQ were positively associated with stronger improvement at T4 and T5. CONCLUSIONS: Short-term ASD-specific add-on group-based psychotherapy has shown postintervention efficacy with regard to parent-rated social responsiveness predominantly in male high-functioning children and adolescents with ASD. Future studies should implement blinded standardized observational measures of peer-related social interaction.
Authors: Jana A Kruppa; Anna Gossen; Eileen Oberwelland Weiß; Gregor Kohls; Nicola Großheinrich; Hannah Cholemkery; Christine M Freitag; Wolfram Karges; Elke Wölfle; Judith Sinzig; Gereon R Fink; Beate Herpertz-Dahlmann; Kerstin Konrad; Martin Schulte-Rüther Journal: Neuropsychopharmacology Date: 2018-11-02 Impact factor: 7.853
Authors: Christine M Freitag; Andreas G Chiocchetti; Afsheen Yousaf; Regina Waltes; Denise Haslinger; Sabine M Klauck; Eftichia Duketis; Michael Sachse; Anette Voran; Monica Biscaldi; Martin Schulte-Rüther; Sven Cichon; Markus Nöthen; Jörg Ackermann; Ina Koch Journal: Transl Psychiatry Date: 2020-07-05 Impact factor: 6.222
Authors: Jennifer A Janusz; Bonita P Klein-Tasman; Jonathan M Payne; Pamela L Wolters; Heather L Thompson; Staci Martin; Peter de Blank; Nicole Ullrich; Allison Del Castillo; Maureen Hussey; Kristina K Hardy; Kristina Haebich; Tena Rosser; Mary Anne Toledo-Tamula; Karin S Walsh Journal: Neurology Date: 2021-07-06 Impact factor: 11.800