Literature DB >> 26712871

FGFR1 Amplification in Squamous Cell Carcinoma of the Lung with Correlation of Primary and Metastatic Tumor Status.

Sara E Monaco1, Erika F Rodriguez2, Alyssa L Mahaffey2, Sanja Dacic2.   

Abstract

BACKGROUND: The FGFR1 gene can be amplified in squamous cell carcinoma of the lung (SqCC). The aim of this study was to compare FGFR1 status with stage and matched primaries with metastases.
METHODS: Cases with FGFR1 fluorescence in situ hybridization (FISH) testing performed from 2000 to 2013 were evaluated for amplification status and clinicopathologic features.
RESULTS: Of the 336 cases tested by FGFR1 FISH, 52 (15%) were positive for amplification. Eight (13%) of 60 N0 cases and eight (17%) of 46 N1 or N2 cases were amplified, with no statistically significant difference. Of the 24 cases with matched primary and metastatic tumors, 22 (92%) were synchronous and one (4%) had discordant amplification.
CONCLUSIONS: Frequency of FGFR1 amplification is similar in SqCC with and without lymph node metastases, but status in metastatic sites may be discordant from the primary in a small subset of cases, which may affect the decision to perform testing of metastatic SqCCs. © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  FGFR; Fibroblast growth factor; Lung; Squamous cell carcinoma

Mesh：

Substances：

Year:  2016        PMID： 26712871     DOI： 10.1093/ajcp/aqv013

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  4 in total

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Journal:  J Mol Diagn       Date:  2017-01       Impact factor: 5.568

2.  Integrative analysis of genetic and epigenetic profiling of lung squamous cell carcinoma (LSCC) patients to identify smoking level relevant biomarkers.

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3.  Phase II Study of AZD4547 in Patients With Tumors Harboring Aberrations in the FGFR Pathway: Results From the NCI-MATCH Trial (EAY131) Subprotocol W.

Authors:  Young K Chae; Fangxin Hong; Christos Vaklavas; Heather H Cheng; Peter Hammerman; Edith P Mitchell; James A Zwiebel; S Percy Ivy; Robert J Gray; Shuli Li; Lisa M McShane; Larry V Rubinstein; David Patton; P Mickey Williams; Stanley R Hamilton; Aaron Mansfield; Barbara A Conley; Carlos L Arteaga; Lyndsay N Harris; Peter J O'Dwyer; Alice P Chen; Keith T Flaherty
Journal:  J Clin Oncol       Date:  2020-05-28       Impact factor: 44.544

4.  Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer.

Authors:  Omar Elakad; Anna-Maria Lois; Katja Schmitz; Sha Yao; Sara Hugo; Laura Lukat; Marc Hinterthaner; Bernhard C Danner; Alexander von Hammerstein-Equord; Kirsten Reuter-Jessen; Hans-Ulrich Schildhaus; Philipp Ströbel; Hanibal Bohnenberger
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  4 in total

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