| Literature DB >> 26711564 |
Danelia Mendieta1, Dora Luz De la Cruz-Aguilera2, Maria Isabel Barrera-Villalpando3, Enrique Becerril-Villanueva4, Rodrigo Arreola5, Erick Hernández-Ferreira6, Sonia Mayra Pérez-Tapia7, Gilberto Pérez-Sánchez8, María Eugenia Garcés-Alvarez9, Lucinda Aguirre-Cruz10, Marco Antonio Velasco-Velázquez11, Lenin Pavón12.
Abstract
Fibromyalgia (FM) is a chronic disease that has been linked to inflammatory reactions and changes in the systemic levels of proinflammatory cytokines that modulate responses in the sympathetic nervous system and hypothalamic-pituitary-adrenal axis. We found that concentrations of IL-6 and IL-8 were elevated in FM patients. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms.Entities:
Keywords: FIQ; Fibromyalgia; IL-6; IL-8; Inflammation
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Year: 2015 PMID： 26711564 DOI： 10.1016/j.jneuroim.2015.11.011
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478