Louiza Belkacemi1, Mahmoud Belalia2. 1. Laboratoire de technologie alimentaire et nutrition, Université Abd ElHamid Ibn Badis, Mostaganem, Algeria. Electronic address: lbelkacemi@hotmail.fr. 2. Laboratoire de structure, Élaboration et application des matériaux moléculaires, Université Abd ElHamid Ibn Badis, Mostaganem, Algeria.
Abstract
AIMS: The magnitude of abnormal liver enzymes profile in type 2 diabetic patients is unknown in Algerian west region even though it counts among liver diseases considered as an important cause of death in type 2 diabetes. The main objective is to assess the prevalence of elevated liver enzymes levels among patients with type 2 diabetes from Algerian west region and to determine associated risk factors. MATERIALS AND METHODS: A descriptive cross sectional study was performed on 180 type 2 diabetic patients in whom anthropometric and biochemical parameters were determined. RESULTS: Twenty-five patients had abnormal elevated alanine transaminase (ALT) (13.9%) with the gender-wise prevalence being 15.9% (n=17) in women and 10.9% (n=8) in men. The prevalence of abnormal elevated aspartate transaminase (AST), gamma glutamyl transferase and alkaline phosphatase level was respectively 10% (n=18), 6.1% (n=11) and 8.9% (16). High waist circumference (OR: 5, CI: 1.04-24.04) and high blood pressure (OR: 4.86, CI: 0.94-25.12) were only associated with elevated AST. Fasting glucose >1.4g/l were associated both with elevated ALT (OR: 3.03, CI: 0.86-10.67) and AST (OR: 5.7, CI: 1.09-29.8). CONCLUSION: A relatively high prevalence of elevated liver enzymes was found in diabetic patients from west Algeria, especially in female patients.
AIMS: The magnitude of abnormal liver enzymes profile in type 2 diabeticpatients is unknown in Algerian west region even though it counts among liver diseases considered as an important cause of death in type 2 diabetes. The main objective is to assess the prevalence of elevated liver enzymes levels among patients with type 2 diabetes from Algerian west region and to determine associated risk factors. MATERIALS AND METHODS: A descriptive cross sectional study was performed on 180 type 2 diabeticpatients in whom anthropometric and biochemical parameters were determined. RESULTS: Twenty-five patients had abnormal elevated alanine transaminase (ALT) (13.9%) with the gender-wise prevalence being 15.9% (n=17) in women and 10.9% (n=8) in men. The prevalence of abnormal elevated aspartate transaminase (AST), gamma glutamyl transferase and alkaline phosphatase level was respectively 10% (n=18), 6.1% (n=11) and 8.9% (16). High waist circumference (OR: 5, CI: 1.04-24.04) and high blood pressure (OR: 4.86, CI: 0.94-25.12) were only associated with elevated AST. Fasting glucose >1.4g/l were associated both with elevated ALT (OR: 3.03, CI: 0.86-10.67) and AST (OR: 5.7, CI: 1.09-29.8). CONCLUSION: A relatively high prevalence of elevated liver enzymes was found in diabeticpatients from west Algeria, especially in female patients.
Authors: David A Brott; Michael J Goodman; Richard P Hermann; Isobel Anderson; Alexandre Kiazand Journal: Drug Des Devel Ther Date: 2020-06-24 Impact factor: 4.162