Literature DB >> 26709327

CLEFT LIP, ALVEOLUS AND PALATE IN AFRICAN NATIVES: AN UPDATE ON DEMOGRAPHICS AND MANAGEMENT OUTCOME.

O B Akintububo1, E O Ojo2, D D Kokong3, S A Adamu4, U U Nnadozie5, Z Yunusa-Kaltungo5, I Jalo6, A M Dauda7.   

Abstract

BACKGROUND: Development of craniofacial structures is a complex process and disruption of any of the numerous steps can lead to development of oro-facial clefts. This is a surgically amenable anomaly as from early life that has had conflicting pattern of demographics reported by various researchers globally. There are several factors that are critical to the surgical outcome.
OBJECTIVE: Study the demographics and the management outcome of cleft lip, alveolus and palate and highlight factors responsible for improved care in recent time.
DESIGN: Descriptive cohort study.
SETTING: Tertiary health institution.
METHOD: All consecutive patients managed for cleft lip, alveolus and palate (CLAP) over 7years and 10months were studied. OUTCOME: Cleft lip, alveolus and palate repair was performed on 149 patients, January 1, 2001- December 31, 2008 with an incidence of 2.1/1000 live births. From this, 27 patients, averaging 4.5 patients per year were operated for the first 6 1/3 years while the remaining 122(81.9%) the next 1 1/2 years, averaging 81.6 patients yearly. Their ages ranged from 3 months - 60 years with 77 (51.7%) males and 72 (48.3.0%) females. Cleft lip was the main presentation in 108(72.5%) of which 72(66.7%) were left sided. Bilateral cleft lip were14 (9.4%). Five (3.4%) patients had associated anomalies out of which 3(60.0%) had CLAP while 2(40.0%) isolated cleft lip or palate. The technique for cleft lip repair was Millard's and Noordhoof's while palatal cleft was the two-flap palatoplasty with intravelar veloplasty. Success was recorded in 142(95.3%) with complication observed in 7(4.7%) patients.
CONCLUSION: The rarity of cleft lip, alveolus and/or palate in the African native documented previously may no longer be tenable as observe in this study. Management outcome has improved owing to the collaboration with SmileTrain, USA, along with multidisciplinary approach.

Entities:  

Keywords:  African Native; Alveolus and Palate; Cleft lip; Demographics; Management Outcome Factors

Year:  2014        PMID: 26709327      PMCID: PMC4689432     

Source DB:  PubMed          Journal:  Afr J Med Med Sci        ISSN: 0309-3913


  14 in total

Review 1.  Cleft lip and palate: understanding genetic and environmental influences.

Authors:  Michael J Dixon; Mary L Marazita; Terri H Beaty; Jeffrey C Murray
Journal:  Nat Rev Genet       Date:  2011-03       Impact factor: 53.242

2.  Pattern of cleft lip and palate [corrected] in Benin City, Nigeria.

Authors:  On Obuekwe; O Akapata
Journal:  Cent Afr J Med       Date:  2004 Jul-Aug

3.  Associated malformations in infants with cleft lip and palate: a prospective, population-based study.

Authors:  Josef Milerad; Ola Larson; Catherina Hagberg; Margareta Ideberg
Journal:  Pediatrics       Date:  1997-08       Impact factor: 7.124

4.  Cleft lip and palate surgery in Kumasi, Ghana: 2001-2005.

Authors:  Peter Donkor; Daniel Owusu Bankas; Pius Agbenorku; Gyikua Plange-Rhule; Samuel K Ansah
Journal:  J Craniofac Surg       Date:  2007-11       Impact factor: 1.046

5.  Epidemiology of cleft lip and cleft palate in Pakistan.

Authors:  Mohammed Mehboob Elahi; Ian T Jackson; Omar Elahi; Ayesha H Khan; Fatima Mubarak; Gul Bano Tariq; Amit Mitra
Journal:  Plast Reconstr Surg       Date:  2004-05       Impact factor: 4.730

Review 6.  Epidemiology of cleft lip and cleft palate in Mississippi.

Authors:  S K Das; R S Runnels; J C Smith; H H Cohly
Journal:  South Med J       Date:  1995-04       Impact factor: 0.954

7.  The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions.

Authors:  Marilyn C Cornelis; Arpana Agrawal; John W Cole; Nadia N Hansel; Kathleen C Barnes; Terri H Beaty; Siiri N Bennett; Laura J Bierut; Eric Boerwinkle; Kimberly F Doheny; Bjarke Feenstra; Eleanor Feingold; Myriam Fornage; Christopher A Haiman; Emily L Harris; M Geoffrey Hayes; John A Heit; Frank B Hu; Jae H Kang; Cathy C Laurie; Hua Ling; Teri A Manolio; Mary L Marazita; Rasika A Mathias; Daniel B Mirel; Justin Paschall; Louis R Pasquale; Elizabeth W Pugh; John P Rice; Jenna Udren; Rob M van Dam; Xiaojing Wang; Janey L Wiggs; Kayleen Williams; Kai Yu
Journal:  Genet Epidemiol       Date:  2010-05       Impact factor: 2.135

8.  A survey of cleft lip and palate management taught in training programs in Korea.

Authors:  Taik Jong Lee; Sang Tae Kim
Journal:  Cleft Palate Craniofac J       Date:  2003-01

9.  Cleft lip and palate in Nigerian children and adults: a comparative study.

Authors:  E O Adekeye; K M Lavery
Journal:  Br J Oral Maxillofac Surg       Date:  1985-12       Impact factor: 1.651

10.  Esophageal impacted dentures.

Authors:  Onyekwere G Nwaorgu; Paul A Onakoya; Olusola A Sogebi; Daniel D Kokong; Oluwole O Dosumu
Journal:  J Natl Med Assoc       Date:  2004-10       Impact factor: 1.798

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