Literature DB >> 26701071

Differentiating Aging Among Adults With Down Syndrome and Comorbid Dementia or Psychopathology.

Anna J Esbensen1, Emily Boshkoff Johnson1, Joseph L Amaral1, Christine M Tan1, Ryan Macks1.   

Abstract

Differences were examined between three groups of adults with Down syndrome in their behavioral presentation, social life/activities, health, and support needs. We compared those with comorbid dementia, with comorbid psychopathology, and with no comorbid conditions. Adults with comorbid dementia were more likely to be older, have lower functional abilities, have worse health and more health conditions, and need more support in self-care. Adults with comorbid psychopathology were more likely to exhibit more behavior problems and to be living at home with their families. Adults with no comorbidities were most likely to be involved in community employment. Differences in behavioral presentation can help facilitate clinical diagnoses in aging in Down syndrome, and implications for differential diagnosis and service supports are discussed.

Entities:  

Keywords:  Down syndrome; aging; dementia; psychopathology

Mesh:

Year:  2016        PMID: 26701071      PMCID: PMC5391688          DOI: 10.1352/1944-7558-121.1.13

Source DB:  PubMed          Journal:  Am J Intellect Dev Disabil        ISSN: 1944-7558


  29 in total

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7.  Differential rates of psychiatric disorders in adults with Down's syndrome compared with other mentally handicapped adults.

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8.  Tooth loss, dementia and neuropathology in the Nun study.

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9.  Long-term impact of parental well-being on adult outcomes and dementia status in individuals with Down syndrome.

Authors:  Anna J Esbensen; Marsha R Mailick; Wayne Silverman
Journal:  Am J Intellect Dev Disabil       Date:  2013-07

10.  Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue.

Authors:  Sophie Poole; Sim K Singhrao; Lakshmyya Kesavalu; Michael A Curtis; StJohn Crean
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2.  Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death.

Authors:  Laura Gennaccaro; Claudia Fuchs; Manuela Loi; Riccardo Pizzo; Sara Alvente; Chiara Berteotti; Leonardo Lupori; Giulia Sagona; Giuseppe Galvani; Antonia Gurgone; Alessandra Raspanti; Giorgio Medici; Marianna Tassinari; Stefania Trazzi; Elisa Ren; Roberto Rimondini; Tommaso Pizzorusso; Giovanna Zoccoli; Maurizio Giustetto; Elisabetta Ciani
Journal:  Aging Dis       Date:  2021-06-01       Impact factor: 6.745

  2 in total

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