Literature DB >> 15000666

Dementia in adults with mental retardation: assessment at a single point in time.

Wayne Silverman1, Nicole Schupf, Warren Zigman, Darlynne Devenny, Charles Miezejeski, Romaine Schubert, Robert Ryan.   

Abstract

Dementia status of 273 adults with mental retardation was rated based upon two extensive evaluations conducted 18 months apart. Overall, 184 individuals did not have dementia, 33 had possible or definite dementia, and 66 had findings suggesting uncertain or questionable status. These ratings were compared to binary classifications (dementia vs. no dementia) generated from the Dementia Questionnaire for Persons With Mental Retardation (Evenhuis, 1995) and the IBR Mental Status Examination (Wisniewski & Hill, 1985). When performance was referenced to IQs (established earlier in adulthood), quantitative criteria effectively distinguished between individuals with and without dementia based upon assessment at a single point in time. Findings suggest that procedures of this type could soon contribute to more accurate and rapid diagnoses of dementia.

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Mesh:

Year:  2004        PMID: 15000666     DOI: 10.1352/0895-8017(2004)109<111:DIAWMR>2.0.CO;2

Source DB:  PubMed          Journal:  Am J Ment Retard        ISSN: 0895-8017


  31 in total

1.  Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns.

Authors:  Edmund C Jenkins; Lingling Ye; Milen Velinov; Sharon J Krinsky-McHale; Warren B Zigman; Nicole Schupf; Wayne P Silverman
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2012-05-16       Impact factor: 3.568

2.  Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events.

Authors:  R J Haier; K Head; E Head; I T Lott
Journal:  Neuroimage       Date:  2007-10-12       Impact factor: 6.556

3.  Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.

Authors:  Nicole Schupf; Joseph H Lee; Michelle Wei; Deborah Pang; Constance Chace; Rong Cheng; Warren B Zigman; Benjamin Tycko; Wayne Silverman
Journal:  Dement Geriatr Cogn Disord       Date:  2008-04-14       Impact factor: 2.959

4.  Change in plasma Aß peptides and onset of dementia in adults with Down syndrome.

Authors:  N Schupf; W B Zigman; M-X Tang; D Pang; R Mayeux; P Mehta; W Silverman
Journal:  Neurology       Date:  2010-11-02       Impact factor: 9.910

5.  Alzheimer's Disease in Adults with Down Syndrome.

Authors:  Warren B Zigman; Darlynne A Devenny; Sharon J Krinsky-McHale; Edmund C Jenkins; Tiina K Urv; Jerzy Wegiel; Nicole Schupf; Wayne Silverman
Journal:  Int Rev Res Ment Retard       Date:  2008-01-01

6.  Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

Authors:  Joseph H Lee; Annie J Lee; Lam-Ha Dang; Deborah Pang; Sergey Kisselev; Sharon J Krinsky-McHale; Warren B Zigman; José A Luchsinger; Wayne Silverman; Benjamin Tycko; Lorraine N Clark; Nicole Schupf
Journal:  Neurobiol Aging       Date:  2017-05-03       Impact factor: 4.673

7.  Stanford-Binet & WAIS IQ Differences and Their Implications for Adults with Intellectual Disability (aka Mental Retardation).

Authors:  Wayne Silverman; Charles Miezejeski; Robert Ryan; Warren Zigman; Sharon Krinsky-McHale; Tiina Urv
Journal:  Intelligence       Date:  2010-03

8.  Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome.

Authors:  Edmund C Jenkins; Lingling Ye; Hong Gu; Samantha A Ni; Charlotte J Duncan; Milen Velinov; Deborah Pang; Sharon J Krinsky-McHale; Warren B Zigman; Nicole Schupf; Wayne P Silverman
Journal:  Neurosci Lett       Date:  2008-06-18       Impact factor: 3.046

9.  Shorter telomeres may indicate dementia status in older individuals with Down syndrome.

Authors:  Edmund C Jenkins; Lingling Ye; Hong Gu; Samantha A Ni; Milen Velinov; Deborah Pang; Sharon J Krinsky-McHale; Warren B Zigman; Nicole Schupf; Wayne P Silverman
Journal:  Neurobiol Aging       Date:  2008-07-16       Impact factor: 4.673

10.  Long-term impact of parental well-being on adult outcomes and dementia status in individuals with Down syndrome.

Authors:  Anna J Esbensen; Marsha R Mailick; Wayne Silverman
Journal:  Am J Intellect Dev Disabil       Date:  2013-07
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