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Literature DB >> 26700490

Epithelial Plasticity versus EMT in Kidney Fibrosis.

Abstract

Ten percent of the population worldwide suffers from chronic kidney disease (CKD), characterized by fibrotic changes in the kidney. Fibrosis is associated with loss of epithelial parenchyma, and accumulation of myofibroblasts, fibrillary collagen, and inflammatory cells. Two recent papers highlight the critical role of Twist and Snai1 transcription factors in kidney fibrosis.

Entities: Chemical Disease Gene Species

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Year: 2015 PMID： 26700490 PMCID： PMC4854190 DOI： 10.1016/j.molmed.2015.11.009

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951

10 in total

1. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.

Authors: Bernhard Bielesz; Yasemin Sirin; Han Si; Thiruvur Niranjan; Antje Gruenwald; Seonho Ahn; Hideki Kato; James Pullman; Manfred Gessler; Volker H Haase; Katalin Susztak
Journal: J Clin Invest Date: 2010-10-18 Impact factor: 14.808

2. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Authors: Berna C Özdemir; Tsvetelina Pentcheva-Hoang; Julienne L Carstens; Xiaofeng Zheng; Chia-Chin Wu; Tyler R Simpson; Hanane Laklai; Hikaru Sugimoto; Christoph Kahlert; Sergey V Novitskiy; Ana De Jesus-Acosta; Padmanee Sharma; Pedram Heidari; Umar Mahmood; Lynda Chin; Harold L Moses; Valerie M Weaver; Anirban Maitra; James P Allison; Valerie S LeBleu; Raghu Kalluri
Journal: Cancer Cell Date: 2014-05-22 Impact factor: 31.743

Review 3. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

Authors: Wilhelm Kriz; Brigitte Kaissling; Michel Le Hir
Journal: J Clin Invest Date: 2011-02 Impact factor: 14.808

4. Evidence that fibroblasts derive from epithelium during tissue fibrosis.

Authors: Masayuki Iwano; David Plieth; Theodore M Danoff; Chengsen Xue; Hirokazu Okada; Eric G Neilson
Journal: J Clin Invest Date: 2002-08 Impact factor: 14.808

5. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.

Authors: Benjamin D Humphreys; Shuei-Liong Lin; Akio Kobayashi; Thomas E Hudson; Brian T Nowlin; Joseph V Bonventre; M Todd Valerius; Andrew P McMahon; Jeremy S Duffield
Journal: Am J Pathol Date: 2009-12-11 Impact factor: 4.307

Review 6. The basics of epithelial-mesenchymal transition.

Authors: Raghu Kalluri; Robert A Weinberg
Journal: J Clin Invest Date: 2009-06 Impact factor: 14.808

Review 7. Molecular mechanisms of diabetic kidney disease.

Authors: Kimberly Reidy; Hyun Mi Kang; Thomas Hostetter; Katalin Susztak
Journal: J Clin Invest Date: 2014-06-02 Impact factor: 14.808

8. Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease.

Authors: M Teresa Grande; Berta Sánchez-Laorden; Cristina López-Blau; Cristina A De Frutos; Agnès Boutet; Miguel Arévalo; R Grant Rowe; Stephen J Weiss; José M López-Novoa; M Angela Nieto
Journal: Nat Med Date: 2015-08-03 Impact factor: 53.440

Review 9. Molecular targets for treatment of kidney fibrosis.

Authors: Peter Y Chuang; Madhav C Menon; John C He
Journal: J Mol Med (Berl) Date: 2012-11-22 Impact factor: 4.599

10. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.

Authors: Sara Lovisa; Valerie S LeBleu; Björn Tampe; Hikaru Sugimoto; Komal Vadnagara; Julienne L Carstens; Chia-Chin Wu; Yohannes Hagos; Birgitta C Burckhardt; Tsvetelina Pentcheva-Hoang; Hersharan Nischal; James P Allison; Michael Zeisberg; Raghu Kalluri
Journal: Nat Med Date: 2015-08-03 Impact factor: 53.440

10 in total

24 in total

1. The impact of mir200 on extracellular matrix topography-guided epithelial-to-mesenchymal transition of prostate cancer cells.

Authors: Tuğba Özdemir
Journal: Turk J Urol Date: 2018-05-31

2. Cyclin G1 and TASCC regulate kidney epithelial cell G₂-M arrest and fibrotic maladaptive repair.

Authors: Guillaume Canaud; Craig R Brooks; Seiji Kishi; Kensei Taguchi; Kenji Nishimura; Sato Magassa; Adam Scott; Li-Li Hsiao; Takaharu Ichimura; Fabiola Terzi; Li Yang; Joseph V Bonventre
Journal: Sci Transl Med Date: 2019-01-23 Impact factor: 17.956

3. Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.

Authors: Ki Wung Chung; Poonam Dhillon; Shizheng Huang; Xin Sheng; Rojesh Shrestha; Chengxiang Qiu; Brett A Kaufman; Jihwan Park; Liming Pei; Joseph Baur; Matthew Palmer; Katalin Susztak
Journal: Cell Metab Date: 2019-08-29 Impact factor: 27.287

Review 4. The next generation of therapeutics for chronic kidney disease.

Authors: Matthew D Breyer; Katalin Susztak
Journal: Nat Rev Drug Discov Date: 2016-05-27 Impact factor: 84.694

5. Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis.

Authors: Verónica Miguel; Jessica Tituaña; J Ignacio Herrero; Laura Herrero; Dolors Serra; Paula Cuevas; Coral Barbas; Diego Rodríguez Puyol; Laura Márquez-Expósito; Marta Ruiz-Ortega; Carolina Castillo; Xin Sheng; Katalin Susztak; Miguel Ruiz-Canela; Jordi Salas-Salvadó; Miguel A Martínez González; Sagrario Ortega; Ricardo Ramos; Santiago Lamas
Journal: J Clin Invest Date: 2021-03-01 Impact factor: 14.808

6. Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells.

Authors: Jessica Venugopal; Jeffrey McDermott; Gladis Sanchez; Madhulika Sharma; Leandro Barbosa; Gail A Reif; Darren P Wallace; Gustavo Blanco
Journal: Exp Cell Res Date: 2017-04-03 Impact factor: 3.905