Literature DB >> 21370523

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

Wilhelm Kriz1, Brigitte Kaissling, Michel Le Hir.   

Abstract

Epithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by which injured renal tubular cells transform into mesenchymal cells that contribute to the development of fibrosis in chronic renal failure. However, an increasing number of studies raise doubts about the existence of this process in vivo. Herein, we review and summarize both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an in vivo process in kidney fibrosis is lacking.

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Year:  2011        PMID： 21370523      PMCID： PMC3026733          DOI： 10.1172/jci44595

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  69 in total

Review 1.  Mechanisms of tubulointerstitial fibrosis.

Authors:  Michael Zeisberg; Eric G Neilson
Journal:  J Am Soc Nephrol       Date:  2010-09-23       Impact factor: 10.121

2.  Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.

Authors:  Bernhard Bielesz; Yasemin Sirin; Han Si; Thiruvur Niranjan; Antje Gruenwald; Seonho Ahn; Hideki Kato; James Pullman; Manfred Gessler; Volker H Haase; Katalin Susztak
Journal:  J Clin Invest       Date:  2010-10-18       Impact factor: 14.808

3.  The interstitial response to renal injury: fibroblast-like cells show phenotypic changes and have reduced potential for erythropoietin gene expression.

Authors:  P H Maxwell; D J Ferguson; L G Nicholls; M H Johnson; P J Ratcliffe
Journal:  Kidney Int       Date:  1997-09       Impact factor: 10.612

4.  Vimentin expression and distal tubular damage in the rat kidney.

Authors:  M Q Zhu; M E De Broe; E J Nouwen
Journal:  Exp Nephrol       Date:  1996 May-Jun

Review 5.  How does podocyte damage result in tubular damage?

Authors:  W Kriz; M Elger; H Hosser; B Hähnel; A Provoost; B Kränzlin; N Gretz
Journal:  Kidney Blood Press Res       Date:  1999       Impact factor: 2.687

6.  Thiazide treatment of rats provokes apoptosis in distal tubule cells.

Authors:  J Loffing; D Loffing-Cueni; I Hegyi; M R Kaplan; S C Hebert; M Le Hir; B Kaissling
Journal:  Kidney Int       Date:  1996-10       Impact factor: 10.612

7.  Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats.

Authors:  Y Y Ng; T P Huang; W C Yang; Z P Chen; A H Yang; W Mu; D J Nikolic-Paterson; R C Atkins; H Y Lan
Journal:  Kidney Int       Date:  1998-09       Impact factor: 10.612

Review 8.  Expression and function of heat shock protein 47: a collagen-specific molecular chaperone in the endoplasmic reticulum.

Authors:  K Nagata
Journal:  Matrix Biol       Date:  1998-02       Impact factor: 11.583

9.  From segmental glomerulosclerosis to total nephron degeneration and interstitial fibrosis: a histopathological study in rat models and human glomerulopathies.

Authors:  W Kriz; H Hosser; B Hähnel; N Gretz; A P Provoost
Journal:  Nephrol Dial Transplant       Date:  1998-11       Impact factor: 5.992

10.  Characteristics of renal tubular atrophy in experimental renovascular hypertension: a model of kidney hibernation.

Authors:  H J Gröne; E Warnecke; C J Olbricht
Journal:  Nephron       Date:  1996       Impact factor: 2.847
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  168 in total

1.  A novel U-STAT3-dependent mechanism mediates the deleterious effects of chronic nicotine exposure on renal injury.

Authors:  Istvan Arany; Dustin K Reed; Samira C Grifoni; Kiran Chandrashekar; George W Booz; Luis A Juncos
Journal:  Am J Physiol Renal Physiol       Date:  2011-12-14

2.  Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve.

Authors:  Kartik Balachandran; Patrick W Alford; Jill Wylie-Sears; Josue A Goss; Anna Grosberg; Joyce Bischoff; Elena Aikawa; Robert A Levine; Kevin Kit Parker
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-28       Impact factor: 11.205

Review 3.  Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases.

Authors:  Paola Nisticò; Mina J Bissell; Derek C Radisky
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-02-01       Impact factor: 10.005

Review 4.  Cellular and molecular mechanisms of renal fibrosis.

Authors:  Youhua Liu
Journal:  Nat Rev Nephrol       Date:  2011-10-18       Impact factor: 28.314

5.  A new Twist in kidney fibrosis.

Authors:  Yossi Ovadya; Valery Krizhanovsky
Journal:  Nat Med       Date:  2015-09       Impact factor: 53.440

6.  Combined silencing of TGF-β2 and Snail genes inhibit epithelial-mesenchymal transition of retinal pigment epithelial cells under hypoxia.

Authors:  Zhuolei Feng; Ruishu Li; Huanqi Shi; Wenjiao Bi; Wenwen Hou; Xiaomei Zhang
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-01-21       Impact factor: 3.117

7.  Discovery and validation of a molecular signature for the noninvasive diagnosis of human renal allograft fibrosis.

Authors:  Dany Anglicheau; Thangamani Muthukumar; Aurélie Hummel; Ruchuang Ding; Vijay K Sharma; Darshana Dadhania; Surya V Seshan; Joseph E Schwartz; Manikkam Suthanthiran
Journal:  Transplantation       Date:  2012-06-15       Impact factor: 4.939

8.  Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis.

Authors:  Rafael Kramann; Flavia Machado; Haojia Wu; Tetsuro Kusaba; Konrad Hoeft; Rebekka K Schneider; Benjamin D Humphreys
Journal:  JCI Insight       Date:  2018-05-03

Review 9.  Host responses in tissue repair and fibrosis.

Authors:  Jeremy S Duffield; Mark Lupher; Victor J Thannickal; Thomas A Wynn
Journal:  Annu Rev Pathol       Date:  2012-10-22       Impact factor: 23.472

10.  Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling.

Authors:  Haili Zhu; Jinlin Liao; Xianke Zhou; Xue Hong; Dongyan Song; Fan Fan Hou; Youhua Liu; Haiyan Fu
Journal:  Kidney Int       Date:  2020-02-17       Impact factor: 10.612
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