Literature DB >> 26692942

MicroRNA-495 suppresses human renal cell carcinoma malignancy by targeting SATB1.

Cai Lv1, Zhiming Bai2, Zhenxiang Liu2, Pengcheng Luo3, Jie Zhang3.   

Abstract

Deregulated expression of miRNAs is related to progression and initiation of human cancers. Although miR-495 has identified in various tumors, its expression and function in renal cell carcinoma (RCC) is still unknown. In this study, we found that the expression of miR-495 was downregulated in RCC cell lines and tissues. Ectopic expression of miR-495 induced G0/G1 phase arrest and suppressed cell proliferation and migration in RCC cell lines. We further validated SATB1 was a direct target of miR-495 in RCC. In addition, re-expression of SATB1 reversed the miR-495-induced inhibition of cell proliferation and migration. These data suggest that miR-495 functions as a tumor suppressor and may be a promising therapeutic target in RCC in the future.

Entities:  

Keywords:  Renal cell carcinoma; SATB1; miR-495; microRNAs

Year:  2015        PMID： 26692942      PMCID： PMC4656775     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  39 in total

1.  MiR-138 induces renal carcinoma cell senescence by targeting EZH2 and is downregulated in human clear cell renal cell carcinoma.

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Journal:  Oncol Res       Date:  2013       Impact factor: 5.574

2.  miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1.

Authors:  W W Hwang-Verslues; P-H Chang; P-C Wei; C-Y Yang; C-K Huang; W-H Kuo; J-Y Shew; K-J Chang; E Y-H P Lee; W-H Lee
Journal:  Oncogene       Date:  2011-01-24       Impact factor: 9.867

3.  Decreased serum miR-181a is a potential new tool for breast cancer screening.

Authors:  Li-Juan Guo; Qing-Yun Zhang
Journal:  Int J Mol Med       Date:  2012-06-11       Impact factor: 4.101

4.  Analysis of hsa-miR-30a-5p expression in human gliomas.

Authors:  Kun Wang; Zhifan Jia; Jian Zou; Anling Zhang; Guangxiu Wang; Jianwei Hao; Yirong Wang; Shuxu Yang; Peiyu Pu
Journal:  Pathol Oncol Res       Date:  2013-04-20       Impact factor: 3.201

5.  The identification of miR-375 as a potential biomarker in distal gastric adenocarcinoma.

Authors:  Wen-Hui Zhang; Jun-Hao Gui; Chang-Zheng Wang; Qing Chang; Shi-Ping Xu; Chang-Hao Cai; Ying-Nan Li; Ya-Ping Tian; Li Yan; Benyan Wu
Journal:  Oncol Res       Date:  2012       Impact factor: 5.574

6.  Epithelial-mesenchymal transition-related microRNA-200s regulate molecular targets and pathways in renal cell carcinoma.

Authors:  Hirofumi Yoshino; Hideki Enokida; Toshihiko Itesako; Shuichi Tatarano; Takashi Kinoshita; Miki Fuse; Satoko Kojima; Masayuki Nakagawa; Naohiko Seki
Journal:  J Hum Genet       Date:  2013-05-02       Impact factor: 3.172

Review 7.  MicroRNA dysregulation in uveal melanoma: a new player enters the game.

Authors:  Zheng Li; Xin Yu; Jianxiong Shen; Yang Jiang
Journal:  Oncotarget       Date:  2015-03-10

8.  Leptin downregulates aggrecan through the p38-ADAMST pathway in human nucleus pulposus cells.

Authors:  Zheng Li; Xin Yu; Jinqian Liang; William Ka Kei Wu; Jun Yu; Jianxiong Shen
Journal:  PLoS One       Date:  2014-10-09       Impact factor: 3.240

9.  Downregulated miR-646 in clear cell renal carcinoma correlated with tumour metastasis by targeting the nin one binding protein (NOB1).

Authors:  W Li; M Liu; Y Feng; Y-F Xu; Y-F Huang; J-P Che; G-C Wang; X-D Yao; J-H Zheng
Journal:  Br J Cancer       Date:  2014-07-10       Impact factor: 7.640

10.  MicroRNA-495 induces breast cancer cell migration by targeting JAM-A.

Authors:  Minghui Cao; Weiwei Nie; Jing Li; Yujing Zhang; Xin Yan; Xiaoxiang Guan; Xi Chen; Ke Zen; Chen-Yu Zhang; Xiaohong Jiang; Dongxia Hou
Journal:  Protein Cell       Date:  2014-07-30       Impact factor: 14.870
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  6 in total

1.  MiR-495 regulates macrophage M1/M2 polarization and insulin resistance in high-fat diet-fed mice via targeting FTO.

Authors:  Fang Hu; Jingkai Tong; Bangli Deng; Jia Zheng; Chengzhi Lu
Journal:  Pflugers Arch       Date:  2019-11-11       Impact factor: 3.657

2.  Circulating microRNA signature of steroid-induced osteonecrosis of the femoral head.

Authors:  Zheng Li; Chao Jiang; Xingye Li; William K K Wu; Xi Chen; Shibai Zhu; Chanhua Ye; Matthew T V Chan; Wenwei Qian
Journal:  Cell Prolif       Date:  2017-12-04       Impact factor: 6.831

3.  MicroRNA-138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9.

Authors:  Bo Hu; Jianbo Wang; Xunbo Jin
Journal:  Oncol Lett       Date:  2017-10-10       Impact factor: 2.967

4.  MicroRNA-495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin-like growth factor receptor-1.

Authors:  Ying Ye; Juhua Zhuang; Guangdong Wang; Saifei He; Suiliang Zhang; Guoyu Wang; Jing Ni; Jiening Wang; Wei Xia
Journal:  Exp Ther Med       Date:  2017-11-08       Impact factor: 2.751

5.  DNA methylation of tumor associated calcium signal transducer 2 (TACSTD2) loci shows association with clinically aggressive renal cell cancers.

Authors:  Olga Katzendorn; Inga Peters; Natalia Dubrowinskaja; Hossein Tezval; Pouriya Faraj Tabrizi; Christoph A von Klot; Jörg Hennenlotter; Marcel Lafos; Markus A Kuczyk; Jürgen Serth
Journal:  BMC Cancer       Date:  2021-04-21       Impact factor: 4.430

6.  MicroRNA-100 Enhances Autophagy and Suppresses Migration and Invasion of Renal Cell Carcinoma Cells via Disruption of NOX4-Dependent mTOR Pathway.

Authors:  Xiumin Liu; Lili Zhong; Ping Li; Peng Zhao
Journal:  Clin Transl Sci       Date:  2020-06-25       Impact factor: 4.438
  6 in total

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