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Literature DB >> 23606081

Analysis of hsa-miR-30a-5p expression in human gliomas.

Kun Wang¹, Zhifan Jia, Jian Zou, Anling Zhang, Guangxiu Wang, Jianwei Hao, Yirong Wang, Shuxu Yang, Peiyu Pu.

Abstract

Our previous study demonstrated that miR-30a-5p was upregulated in six malignant glioma cell lines by microRNA(miRNA) array. For further verification of this finding, the expression of miR-30a-5p in 7 more malignant glioma cell lines, 43 freshly resected glioma samples and 75 archival paraffin embedded glioma specimens with different grade of malignancy were examined by qRT-PCR and in situ hybridization(ISH). Here, we present the first evidence that miR-30a-5p is overexpressed in glioma cell lines and glioma samples as compared to the normal brain tissues (NBTs), and its expression level is positively correlated with tumor grade of malignancy. It is concluded that miR-30a-5p may have the potential as a diagnostic or prognostic marker of gliomas and as the target of miRNA-based glioma therapy in further studies.

Entities: Chemical Disease Gene Species

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Year: 2013 PMID： 23606081 DOI： 10.1007/s12253-012-9593-x

Source DB: PubMed Journal: Pathol Oncol Res ISSN： 1219-4956 Impact factor: 3.201

33 in total

1. High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma.

Authors: Markus Metzler; Monika Wilda; Kerstin Busch; Susanne Viehmann; Arndt Borkhardt
Journal: Genes Chromosomes Cancer Date: 2004-02 Impact factor: 5.006

2. The role of microRNA genes in papillary thyroid carcinoma.

Authors: Huiling He; Krystian Jazdzewski; Wei Li; Sandya Liyanarachchi; Rebecca Nagy; Stefano Volinia; George A Calin; Chang-Gong Liu; Kaarle Franssila; Saul Suster; Richard T Kloos; Carlo M Croce; Albert de la Chapelle
Journal: Proc Natl Acad Sci U S A Date: 2005-12-19 Impact factor: 11.205

3. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells.

Authors: F Yu; H Deng; H Yao; Q Liu; F Su; E Song
Journal: Oncogene Date: 2010-05-24 Impact factor: 9.867

4. Extensive modulation of a set of microRNAs in primary glioblastoma.

Authors: S A Ciafrè; S Galardi; A Mangiola; M Ferracin; C-G Liu; G Sabatino; M Negrini; G Maira; C M Croce; M G Farace
Journal: Biochem Biophys Res Commun Date: 2005-09-09 Impact factor: 3.575

5. Temozolomide-mediated radiosensitization of human glioma cells in a zebrafish embryonic system.

Authors: Geoffrey A Geiger; Weili Fu; Gary D Kao
Journal: Cancer Res Date: 2008-05-01 Impact factor: 12.701

6. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

Authors: George Adrian Calin; Cinzia Sevignani; Calin Dan Dumitru; Terry Hyslop; Evan Noch; Sai Yendamuri; Masayoshi Shimizu; Sashi Rattan; Florencia Bullrich; Massimo Negrini; Carlo M Croce
Journal: Proc Natl Acad Sci U S A Date: 2004-02-18 Impact factor: 11.205

7. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.

Authors: Aaron J Schetter; Suet Yi Leung; Jane J Sohn; Krista A Zanetti; Elise D Bowman; Nozomu Yanaihara; Siu Tsan Yuen; Tsun Leung Chan; Dora L W Kwong; Gordon K H Au; Chang-Gong Liu; George A Calin; Carlo M Croce; Curtis C Harris
Journal: JAMA Date: 2008-01-30 Impact factor: 56.272

8. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival.

Authors: Junichi Takamizawa; Hiroyuki Konishi; Kiyoshi Yanagisawa; Shuta Tomida; Hirotaka Osada; Hideki Endoh; Tomoko Harano; Yasushi Yatabe; Masato Nagino; Yuji Nimura; Tetsuya Mitsudomi; Takashi Takahashi
Journal: Cancer Res Date: 2004-06-01 Impact factor: 12.701

9. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.

Authors: Ramiro Garzon; Stefano Volinia; Chang-Gong Liu; Cecilia Fernandez-Cymering; Tiziana Palumbo; Flavia Pichiorri; Muller Fabbri; Kevin Coombes; Hansjuerg Alder; Tatsuya Nakamura; Neal Flomenberg; Guido Marcucci; George A Calin; Steven M Kornblau; Hagop Kantarjian; Clara D Bloomfield; Michael Andreeff; Carlo M Croce
Journal: Blood Date: 2008-01-10 Impact factor: 22.113

10. miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.

Authors: Jincheng Li; Stefan Donath; Yanrui Li; Danian Qin; Bellur S Prabhakar; Peifeng Li
Journal: PLoS Genet Date: 2010-01-08 Impact factor: 5.917

18 in total

1. miR-211 promotes non-small cell lung cancer proliferation by targeting SRCIN1.

Authors: Leiguang Ye; Hui Wang; Baogang Liu
Journal: Tumour Biol Date: 2015-08-16

2. MicroRNA-30a-5p suppresses proliferation, invasion and tumor growth of hepatocellular cancer cells via targeting FOXA1.

Authors: Shuliang Zhang; Qin Liu; Qi Zhang; Ling Liu
Journal: Oncol Lett Date: 2017-08-10 Impact factor: 2.967

Analysis of hsa-miR-30a-5p expression in human gliomas.

1. High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma.

2. The role of microRNA genes in papillary thyroid carcinoma.

3. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells.

4. Extensive modulation of a set of microRNAs in primary glioblastoma.

5. Temozolomide-mediated radiosensitization of human glioma cells in a zebrafish embryonic system.

6. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

7. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.

8. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival.

9. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.

10. miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.

1. miR-211 promotes non-small cell lung cancer proliferation by targeting SRCIN1.

2. MicroRNA-30a-5p suppresses proliferation, invasion and tumor growth of hepatocellular cancer cells via targeting FOXA1.

3. MicroRNA-30a suppresses non-small-cell lung cancer by targeting Myb-related protein B.

4. MicroRNA-495 suppresses human renal cell carcinoma malignancy by targeting SATB1.

5. miR-506 inhibits the proliferation and invasion by targeting IGF2BP1 in glioblastoma.

Review 6. MicroRNA dysregulation in rhabdomyosarcoma: a new player enters the game.

7. Comprehensive analysis of the LncRNAs, MiRNAs, and MRNAs acting within the competing endogenous RNA network of LGG.

8. miR-372 suppresses tumour proliferation and invasion by targeting IGF2BP1 in renal cell carcinoma.

9. MicroRNA-613 inhibited ovarian cancer cell proliferation and invasion by regulating KRAS.

10. MiR-506 suppresses tumor proliferation and invasion by targeting FOXQ1 in nasopharyngeal carcinoma.