Patompong Ungprasert1,2, Narat Srivali3, Wonngarm Kittanamongkolchai4. 1. Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. 2. Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. 3. Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. 4. Division ofNephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Abstract
AIMS: Patients with rheumatoid arthritis (RA) might be at an increased risk of developing atrial fibrillation (AF) as a result of deleterious effects of inflammatory cytokines on cardiomyocytes. This study aimed to comprehensively review all available evidence to further characterize this possible association. METHODS: We conducted a systematic review and meta-analysis of cohort studies that reported relative risk, hazard ratio, incidence ratio or standardized incidence ratio with 95% confidence intervals comparing the risk of incidence of AF in patients with RA versus non-RA participants. Pooled risk ratio and 95% confidence interval were calculated using random-effect, generic inverse-variance methods of DerSimonian and Laird. RESULTS: Three retrospective cohort studies with 39 912 cases of RA and 4 269 161 non-RA controls were included in the data analysis. The pooled risk ratio of subsequent development of AF in patients with RA versus controls was 1.29 (95% CI, 1.05-1.59). The statistical heterogeneity was moderate with an I2 of 71%. CONCLUSION: Our meta-analysis demonstrated a statistically significant increased risk of subsequent development of AF among patients with RA.
AIMS: Patients with rheumatoid arthritis (RA) might be at an increased risk of developing atrial fibrillation (AF) as a result of deleterious effects of inflammatory cytokines on cardiomyocytes. This study aimed to comprehensively review all available evidence to further characterize this possible association. METHODS: We conducted a systematic review and meta-analysis of cohort studies that reported relative risk, hazard ratio, incidence ratio or standardized incidence ratio with 95% confidence intervals comparing the risk of incidence of AF in patients with RA versus non-RA participants. Pooled risk ratio and 95% confidence interval were calculated using random-effect, generic inverse-variance methods of DerSimonian and Laird. RESULTS: Three retrospective cohort studies with 39 912 cases of RA and 4 269 161 non-RA controls were included in the data analysis. The pooled risk ratio of subsequent development of AF in patients with RA versus controls was 1.29 (95% CI, 1.05-1.59). The statistical heterogeneity was moderate with an I2 of 71%. CONCLUSION: Our meta-analysis demonstrated a statistically significant increased risk of subsequent development of AF among patients with RA.
Authors: Alessandro Maloberti; Marta Riva; Marijana Tadic; Carlo Valena; Paolo Villa; Ilenia Boggioni; Maria Rosa Pozzi; Guido Grassi Journal: High Blood Press Cardiovasc Prev Date: 2018-01-12
Authors: Vivian K Kawai; Mingjian Shi; Qiping Feng; Cecilia P Chung; Ge Liu; Nancy J Cox; Gail P Jarvik; Ming T M Lee; Scott J Hebbring; John B Harley; Kenneth M Kaufman; Bahram Namjou; Eric Larson; Adam S Gordon; Dan M Roden; C Michael Stein; Jonathan D Mosley Journal: Arthritis Rheumatol Date: 2020-08-06 Impact factor: 15.483