Literature DB >> 26687217

BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders.

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Abstract

We outline an ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls. Initially focused on schizophrenia and mood disorders, the goal of this consortium is to elucidate the underlying molecular mechanisms of genetic associations with the goal of identifying novel therapeutic targets. The consortium currently consists of seven pharmaceutical companies and a not-for-profit medical research institution working as a precompetitive team to generate and analyze publicly available archival brain genomic data related to neuropsychiatric illness.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26687217     DOI： 10.1016/j.neuron.2015.10.047

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  31 in total

1.  PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity.

Authors:  Yifan Yu; Teresa Niccoli; Ziyu Ren; Nathaniel S Woodling; Benjamin Aleyakpo; Gyorgy Szabadkai; Linda Partridge
Journal:  Hum Mol Genet       Date:  2020-08-11       Impact factor: 6.150

2.  Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia.

Authors:  Leonardo Collado-Torres; Emily E Burke; Amy Peterson; JooHeon Shin; Richard E Straub; Anandita Rajpurohit; Stephen A Semick; William S Ulrich; Amanda J Price; Cristian Valencia; Ran Tao; Amy Deep-Soboslay; Thomas M Hyde; Joel E Kleinman; Daniel R Weinberger; Andrew E Jaffe
Journal:  Neuron       Date:  2019-06-04       Impact factor: 17.173

3.  Reply to Lyon et al.: Self-regulation and the foraging gene: From flies to humans.

Authors:  Marla B Sokolowski; Abigail A Scholer; James Danckert
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-23       Impact factor: 11.205

4.  Availability of public databases for triangulation of findings.

Authors:  Matthew Lyon; Marcus Munafo; Tom Gaunt; George Davey Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-23       Impact factor: 11.205

Review 5.  Searching for convergent pathways in autism spectrum disorders: insights from human brain transcriptome studies.

Authors:  Akira Gokoolparsadh; Gavin J Sutton; Alexiy Charamko; Nicole F Oldham Green; Christopher J Pardy; Irina Voineagu
Journal:  Cell Mol Life Sci       Date:  2016-07-12       Impact factor: 9.261

Review 6.  Biophysical Modeling of Large-Scale Brain Dynamics and Applications for Computational Psychiatry.

Authors:  John D Murray; Murat Demirtaş; Alan Anticevic
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2018-07-19

Review 7.  Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.

Authors:  Emily L Ricq; Jacob M Hooker; Stephen J Haggarty
Journal:  Psychiatry Clin Neurosci       Date:  2016-09-07       Impact factor: 5.188

Review 8.  A Genetics Perspective on the Role of the (Neuro)Immune System in Schizophrenia.

Authors:  Rebecca Birnbaum; Daniel R Weinberger
Journal:  Schizophr Res       Date:  2019-03-05       Impact factor: 4.939

Review 9.  The epigenomics of schizophrenia, in the mouse.

Authors:  Behnam Javidfar; Royce Park; Bibi S Kassim; Lucy K Bicks; Schahram Akbarian
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2017-07-12       Impact factor: 3.568

Review 10.  Discovery, Development, and Adoption of Medications to Treat Alcohol Use Disorder: Goals for the Phases of Medications Development.

Authors:  Raye Z Litten; Daniel E Falk; Megan L Ryan; Joanne B Fertig
Journal:  Alcohol Clin Exp Res       Date:  2016-05-17       Impact factor: 3.455
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