| Literature DB >> 26684850 |
Luciana G da S Souza1, Macia C S Almeida1, Telma L G Lemos2, Paulo R V Ribeiro3, Edy S de Brito3, Vera L M Silva4, Artur M S Silva5, Raimundo Braz-Filho6, José G M Costa7, Fábio F G Rodrigues7, Francisco S Barreto8, Manoel O de Moraes8.
Abstract
Biflorin 1 is a biologically active quinone, isolated from Capraria biflora. Five new biflorin-based nitrogen derivatives were synthesized, of which two were mixtures of (E)- and (Z)- isomers: (Z)-2a, (Z)-2b, (Z)-3a, (Z)- and (E)-3b, (Z)- and (E)-3c. The antibacterial activity was investigated using the microdilution method for determining the minimum inhibitory concentration (MIC) against six bacterial strains. Tests have shown that these derivatives have potential against all bacterial strains. The cytotoxic activity was also evaluated against three strains of cancer cells, but none of the derivatives showed activity.Entities:
Keywords: Antibacterial; Antitumoral; Biflorin; Hydrazones; Oximes
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Year: 2015 PMID： 26684850 DOI： 10.1016/j.bmcl.2015.11.095
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823