Literature DB >> 2668447

An immunohistochemical study of beta-protein in Alzheimer-type dementia brains.

H Arai1, N Sagi, I Noguchi, S Haga, T Ishii, Y Makino, K Kosaka.   

Abstract

An immunohistochemical study with a polyclonal anti-beta-protein antiserum was performed in order to understand the mechanism of deposition of amyloid fibrils in senile plaques in Alzheimer-type dementia (ATD). Serial cortical sections cut from ATD brains were necessary to investigate the structural correlation between senile plaques and blood vessels. The senile plaques were stained well and a blood vessel or capillary-like structure was found in most of beta-protein-immunoreactive deposits. These findings may suggest an involvement of blood vessels in the formation of at least some of the amyloid deposits in ATD brains.

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Year:  1989        PMID： 2668447     DOI： 10.1007/bf00314502

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  19 in total

1.  Enzyme histochemical studies of senile plaques and the plaque-like degeneration of arteries and capillaries (Scholz).

Authors:  T Ishii
Journal:  Acta Neuropathol       Date:  1969       Impact factor: 17.088

2.  High molecular weight Alzheimer's disease amyloid peptide immunoreactivity in human serum and CSF is an immunoglobulin G.

Authors:  W M Pardridge; H V Vinters; B L Miller; W W Tourtellotte; J B Eisenberg; J Yang
Journal:  Biochem Biophys Res Commun       Date:  1987-05-29       Impact factor: 3.575

3.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.

Authors:  G G Glenner; C W Wong
Journal:  Biochem Biophys Res Commun       Date:  1984-05-16       Impact factor: 3.575

4.  In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

Authors:  M L Cohen; T E Golde; M F Usiak; L H Younkin; S G Younkin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

5.  Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.

Authors:  C W Wong; V Quaranta; G G Glenner
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

6.  Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease.

Authors:  S Bahmanyar; G A Higgins; D Goldgaber; D A Lewis; J H Morrison; M C Wilson; S K Shankar; D C Gajdusek
Journal:  Science       Date:  1987-07-03       Impact factor: 47.728

7.  Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Authors:  C L Masters; G Simms; N A Weinman; G Multhaup; B L McDonald; K Beyreuther
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

8.  An unusual type of pre-senile dementia (atypical Alzheimer's disease with amyloid vascular change).

Authors:  J A CORSELLIS; J B BRIERLEY
Journal:  Brain       Date:  1954-12       Impact factor: 13.501

9.  Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

Authors:  R E Tanzi; J F Gusella; P C Watkins; G A Bruns; P St George-Hyslop; M L Van Keuren; D Patterson; S Pagan; D M Kurnit; R L Neve
Journal:  Science       Date:  1987-02-20       Impact factor: 47.728

10.  Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

Authors:  C L Masters; G Multhaup; G Simms; J Pottgiesser; R N Martins; K Beyreuther
Journal:  EMBO J       Date:  1985-11       Impact factor: 11.598
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  7 in total

1.  The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease.

Authors:  M Kawai; R N Kalaria; S I Harik; G Perry
Journal:  Am J Pathol       Date:  1990-12       Impact factor: 4.307

Review 2.  Alzheimer's disease, brain immune privilege and memory: a hypothesis.

Authors:  Y I Arshavsky
Journal:  J Neural Transm (Vienna)       Date:  2006-08-24       Impact factor: 3.575

3.  Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.

Authors:  Samir Kumar-Singh; Daniel Pirici; Eileen McGowan; Sally Serneels; Chantal Ceuterick; John Hardy; Karen Duff; Dennis Dickson; Christine Van Broeckhoven
Journal:  Am J Pathol       Date:  2005-08       Impact factor: 4.307

4.  Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques.

Authors:  M A Pappolla; R A Omar; H V Vinters
Journal:  Am J Pathol       Date:  1991-09       Impact factor: 4.307

5.  Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric.

Authors:  Samir Kumar-Singh; Patrick Cras; Rong Wang; John M Kros; Johan van Swieten; Ursula Lübke; Chantal Ceuterick; Sally Serneels; Krist'l Vennekens; Jean-Pierre Timmermans; Eric Van Marck; Jean-Jacques Martin; Cornelia M van Duijn; Christine Van Broeckhoven
Journal:  Am J Pathol       Date:  2002-08       Impact factor: 4.307

6.  Amyloid-P-component-like immunoreactivity in beta/A4-immunoreactive deposits in Alzheimer-type dementia brains.

Authors:  M Kimura; H Arai; T Takahashi; N Iwamoto
Journal:  J Neurol       Date:  1994-01       Impact factor: 4.849

Review 7.  Microvascular pathology and vascular basement membrane components in Alzheimer's disease.

Authors:  L S Perlmutter
Journal:  Mol Neurobiol       Date:  1994 Aug-Dec       Impact factor: 5.590
  7 in total

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