Shirou Ishii1, Daisuke Shimao2, Takamitsu Hara3, Masayuki Miyajima4, Ken Kikuchi4, Masashi Takawa5, Kensuke Kumamoto5, Hiroshi Ito3, Fumio Shishido4. 1. Department of Radiology, Fukushima Medical University Hospital, 1, Hikarigaoka, Fukushima, Fukushima Prefecture, Japan. shirou@fmu.ac.jp. 2. Department of Radiological Technology, Faculty of Health Sciences, Hokkaido University of Science, Sapporo, Hokkaido, Japan. 3. Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan. 4. Department of Radiology, Fukushima Medical University Hospital, 1, Hikarigaoka, Fukushima, Fukushima Prefecture, Japan. 5. Department of Organ Regulatory Surgery, Fukushima Medical University, Fukushima, Japan.
Abstract
PURPOSE: To compare the diagnostic accuracy of whole-body PET/CT and integrated PET/MR in relation to the total scan time durations. METHODS: One hundred and twenty-three (123) patients (40 males and 83 females; mean age 59.6 years; range 20-83 years) with confirmed primary cancer and clinical suspicion of metastatic disease underwent whole-body 18F-FDG-PET/CT and 18F-FDG-PET/MR. Data acquisition was done after intravenous administration of 110-301 MBq radioactivity of 18F-FDG, and PET/MR data were acquired after the PET/CT data acquisition. The mean uptake times for PET/CT and PET/MR acquisition were 68.0 ± 8.0 and 98.0 ± 14 min, respectively. Total scan time was 20.0 and 25.0 min for whole-body PET/CT and PET/MR imaging. RESULTS: The reconstructed PET/CT and PET/MR data detected 333/355 (93.8 %) common lesions in 111/123 (90.2 %) patients. PET/CT and PET/MR alone detected 348/355 and 340/355 lesions, respectively. No significant (p = 0.08) difference was observed for the overall detection efficiency between the two techniques. On the other hand, a significant difference was observed between the two techniques for the detection of lung (p = 0.003) and cerebrospinal (p = 0.007) lesions. The 15 lesions identified by PET/CT only included 8 lung, 3 lymph nodes, 2 bone, and 1 each of peritoneal and adrenal gland lesions. On the other hand, 7 (6 brain metastatic lesions and 1 bone lesion) were identified by PET/MR only. CONCLUSION: Integrated PET/MR is a feasible whole-body imaging modality and may score better than PET/CT for the detection of brain metastases. To further prove diagnostic utility, this technique requires further clinical validation.
PURPOSE: To compare the diagnostic accuracy of whole-body PET/CT and integrated PET/MR in relation to the total scan time durations. METHODS: One hundred and twenty-three (123) patients (40 males and 83 females; mean age 59.6 years; range 20-83 years) with confirmed primary cancer and clinical suspicion of metastatic disease underwent whole-body 18F-FDG-PET/CT and 18F-FDG-PET/MR. Data acquisition was done after intravenous administration of 110-301 MBq radioactivity of 18F-FDG, and PET/MR data were acquired after the PET/CT data acquisition. The mean uptake times for PET/CT and PET/MR acquisition were 68.0 ± 8.0 and 98.0 ± 14 min, respectively. Total scan time was 20.0 and 25.0 min for whole-body PET/CT and PET/MR imaging. RESULTS: The reconstructed PET/CT and PET/MR data detected 333/355 (93.8 %) common lesions in 111/123 (90.2 %) patients. PET/CT and PET/MR alone detected 348/355 and 340/355 lesions, respectively. No significant (p = 0.08) difference was observed for the overall detection efficiency between the two techniques. On the other hand, a significant difference was observed between the two techniques for the detection of lung (p = 0.003) and cerebrospinal (p = 0.007) lesions. The 15 lesions identified by PET/CT only included 8 lung, 3 lymph nodes, 2 bone, and 1 each of peritoneal and adrenal gland lesions. On the other hand, 7 (6 brain metastatic lesions and 1 bone lesion) were identified by PET/MR only. CONCLUSION: Integrated PET/MR is a feasible whole-body imaging modality and may score better than PET/CT for the detection of brain metastases. To further prove diagnostic utility, this technique requires further clinical validation.
Authors: Sandra Saade-Lemus; Elad Nevo; Iman Soliman; Hansel J Otero; Ralph W Magee; Elizabeth T Drum; Lisa J States Journal: Pediatr Radiol Date: 2020-02-19
Authors: Marius E Mayerhoefer; Helmut Prosch; Lucian Beer; Dietmar Tamandl; Thomas Beyer; Christoph Hoeller; Dominik Berzaczy; Markus Raderer; Matthias Preusser; Maximilian Hochmair; Barbara Kiesewetter; Christian Scheuba; Ahmed Ba-Ssalamah; Georgios Karanikas; Julia Kesselbacher; Gerald Prager; Karin Dieckmann; Stephan Polterauer; Michael Weber; Ivo Rausch; Bernhard Brauner; Harald Eidherr; Wolfgang Wadsak; Alexander R Haug Journal: Eur J Nucl Med Mol Imaging Date: 2019-08-13 Impact factor: 9.236
Authors: Sui Wai Ling; Anouk C de Jong; Ivo G Schoots; Kazem Nasserinejad; Martijn B Busstra; Astrid A M van der Veldt; Tessa Brabander Journal: Eur Urol Open Sci Date: 2021-09-28