J J Zhou1, S Zheng1. 1. Department of Surgical Oncology, Second Affiliated Hospital, and The Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China.
Abstract
BACKGROUND: Colorectal cancer (CRC) still accounts for high mortality and morbidity of cancer patients worldwide. Early detection screening and therapeutic management of CRC are still traditional, with some important progress including cetuximab, microsatellite instability and the concept of CRC intrinsic subtypes. SUMMARY: Most achievements are derived from translational cancer research. Translational cancer research attempts to better understand the heterogeneity of human cancer and further turn discoveries into benefits for cancer patients. The four basic strategies of translational research can be depicted as (a) biomarker discovery, (b) identification in xenografts, (c) population-based verification and (d) clinical validation.
BACKGROUND:Colorectal cancer (CRC) still accounts for high mortality and morbidity of cancerpatients worldwide. Early detection screening and therapeutic management of CRC are still traditional, with some important progress including cetuximab, microsatellite instability and the concept of CRC intrinsic subtypes. SUMMARY: Most achievements are derived from translational cancer research. Translational cancer research attempts to better understand the heterogeneity of humancancer and further turn discoveries into benefits for cancerpatients. The four basic strategies of translational research can be depicted as (a) biomarker discovery, (b) identification in xenografts, (c) population-based verification and (d) clinical validation.
Entities:
Keywords:
Colorectal neoplasms; Therapeutics; Translational medical research
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