Literature DB >> 266736

Association of e antigen with Dane particle DNA in sera from asymptomatic carriers of hepatitis B surface antigen.

B G Werner, A P O'Connell, J Summers.   

Abstract

Sera containing hepatitis B surface antigen from 30 asymptomatic blood donors were assayed for e antigen (HBeAg) and antibody to e antigen (anti-HBe) by rheophoresis,. Fourteen samples (47%) had detectable HBeAg, ten (33%) had anti-HBe, and six (20%) had neither. DNA was extracted from 26 of these sera and assayed for its ability to anneal to a [32P]-DNA probe that is a copy of Dane particle DNA. All 10 HBeAg-positive samples tested contained DNA that formed specific hybrids with the DNA probe, as did one of 10 anti HBe-positive samples. Hybridization was not detected in nine sera containing anti-HBe and six sera without HBeAg or anti-HBe. Because the Dane particle is thought to be the hepatitis B virus, this association between HBeAg positivity and Dane particle DNA strongly supports the hypothesis that e antigen is a marker of the presence of the virus and, consequently, potential infectivity.

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Year:  1977        PMID： 266736      PMCID： PMC431093          DOI： 10.1073/pnas.74.5.2149

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Hepatitis B antigen-associated deoxyribonucleic acid polymerase activity and e antigen/anti-e system.

Authors:  M Imai; F C Tachibana; Y Moritsugu; Y Miyakawa; M Mayumi
Journal:  Infect Immun       Date:  1976-09       Impact factor: 3.441

2.  "e" Antigen, Dane particles, and serum DNA polymerase activity in HBsAg carriers.

Authors:  S H Hindman; C R Gravelle; B L Murphy; D W Bradley; W R Budge; J E Maynard
Journal:  Ann Intern Med       Date:  1976-10       Impact factor: 25.391

3.  Incidence and meaning of the "e" determinant among hepatitis-B-antigen positive patients with acute and chronic liver diseases. Report from the Copenhagen Hepatitis Acuta Programme.

Authors:  J O Nielsen; O Dietrichson; E Juhl
Journal:  Lancet       Date:  1974-10-19       Impact factor: 79.321

4.  e/anti-e in hepatitis B, an antibody/anti-antibody system.

Authors:  A R Neurath; N Strick
Journal:  Lancet       Date:  1977-01-15       Impact factor: 79.321

5.  Letter: Detection of e antigen by immunofluorescence in cytoplasm of hepatocytes of HBsAg carriers.

Authors:  C Trepo; L Vitvitski; R Neurath; N Hashimoto; R Schaefer; G Nemoz
Journal:  Lancet       Date:  1976-02-28       Impact factor: 79.321

6.  A new antigen complex co-occurring with Australia antigen.

Authors:  L O Magnius; A Espmark
Journal:  Acta Pathol Microbiol Scand B Microbiol Immunol       Date:  1972

7.  Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure.

Authors:  H J Alter; L B Seeff; P M Kaplan; V J McAuliffe; E C Wright; J L Gerin; R H Purcell; P V Holland; H J Zimmerman
Journal:  N Engl J Med       Date:  1976-10-21       Impact factor: 91.245

8.  Hepatitis and hepatitis B-antigen in Greenland. II: Occurrence and interrelation of hepatitis B associated surface, core, and "e" antigen-antibody systems in a highly endemic area.

Authors:  P Skinhoj
Journal:  Am J Epidemiol       Date:  1977-02       Impact factor: 4.897

9.  The e antigen and vertical transmission of hepatitis B surface antigen.

Authors:  R P Beasley; C Trepo; C E Stevens; W Szmuness
Journal:  Am J Epidemiol       Date:  1977-02       Impact factor: 4.897

10.  Detection of e antigen and antibody: correlations with hapatitis B surface and hepatitis B core antigens, liver disease, and outcome in hepatitis B infections.

Authors:  C G Trepo; L O Magnius; R A Schaefer; A M Prince
Journal:  Gastroenterology       Date:  1976-11       Impact factor: 22.682
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  6 in total

1.  The significance of the HBeAg/anti-HBe system in hemodialysis patients. A multicenter study.

Authors:  F Fiaccadori; S David; G Faggion; N Feriani; C Ferrari; V Franco; T Giuberti; C Grutta D'Auria; G La Greca; G Magnani
Journal:  Infection       Date:  1984 Jan-Feb       Impact factor: 3.553

2.  Viral hepatitis A and B in hemodialysed patients.

Authors:  K Gmelin; B von Ehrlich; B Kommerell; E Ritz; J Bommer
Journal:  Klin Wochenschr       Date:  1980-04-01

3.  Incidence of hepatitis B virus DNA and DNA-polymerase in sera of Italian asymptomatic carriers with the serological markers of HBV.

Authors:  G Carloni; C Delfini; S Colloca; E Alfani; G Taliani; C De Bac
Journal:  Arch Virol       Date:  1986       Impact factor: 2.574

4.  Duality of hepatitis B e antigen in serum of persons infected with hepatitis B virus: evidence for the nonidentity of e antigen with immunoglobulins.

Authors:  K Takahashi; M Imai; Y Miyakawa; S Iwakiri; M Mayumi
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

5.  Localization and nucleotide sequence of the gene coding for the woodchuck hepatitis virus surface antigen: comparison with the gene coding for the human hepatitis B virus surface antigen.

Authors:  F Galibert; T N Chen; E Mandart
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

6.  Hepatitis B virus DNA detected in formalin-fixed liver specimens and its relation to serologic markers and histopathologic features in chronic liver disease.

Authors:  P J Rijntjes; T J Van Ditzhuijsen; A M Van Loon; U J Van Haelst; F B Bronkhorst; S H Yap
Journal:  Am J Pathol       Date:  1985-09       Impact factor: 4.307
  6 in total

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