Defining the Risk of Small Polyps: Potential Value of CTC.

Although the clinical importance of large colorectal polyps and the benign nature of diminutive polyps are generally accepted, elucidating the clinical significance of small polyps (6-9 mm) could have an enormous impact on colorectal cancer (CRC) screening. Serial volumetric measurement via CTC may be a valuable method for assessing changes in polyp size. With the recognition of alternative CRC pathways, a more precise understanding of the natural history of small colorectal polyps is needed and data such as those reported by Nolthenius contribute to that knowledge.