Literature DB >> 26668776

The role of L-type amino acid transporter 1 in human tumors.

Yu Zhao1, Lin Wang1, Jihong Pan2.   

Abstract

L-type amino acid transporter 1 (LAT1) is an L-type amino acid transporter and transports large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine. LAT1 was found to be highly expressed especially in human cancer tissues, and up-regulated LAT1 can lead to dysfunction in human tumor cells. These findings suggest that LAT1 plays an important role in human tumors. This review provides an overview of the current understanding of LAT1 expression and its clinical significance and function in tumors.

Entities:  

Keywords:  LAT1; angiogenesis; human tumor; proliferation

Year:  2015        PMID： 26668776      PMCID： PMC4660857          DOI： 10.5582/irdr.2015.01024

Source DB:  PubMed          Journal:  Intractable Rare Dis Res        ISSN： 2186-3644


  41 in total

1.  Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.

Authors:  Qian Wang; Charles G Bailey; Cynthia Ng; Jessamy Tiffen; Annora Thoeng; Vineet Minhas; Melanie L Lehman; Stephen C Hendy; Grant Buchanan; Colleen C Nelson; John E J Rasko; Jeff Holst
Journal:  Cancer Res       Date:  2011-10-17       Impact factor: 12.701

2.  JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells.

Authors:  Dae-Woong Yun; Seul Ah Lee; Min-Gyeong Park; Jae-Sung Kim; Sun-Kyoung Yu; Mi-Ra Park; Su-Gwan Kim; Ji-Su Oh; Chun Sung Kim; Heung-Joong Kim; Jin-Soo Kim; Hong Sung Chun; Yoshikatsu Kanai; Hitoshi Endou; Michael F Wempe; Do Kyung Kim
Journal:  J Pharmacol Sci       Date:  2014-02-04       Impact factor: 3.337

3.  A simple method for displaying the hydropathic character of a protein.

Authors:  J Kyte; R F Doolittle
Journal:  J Mol Biol       Date:  1982-05-05       Impact factor: 5.469

4.  Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in surgically resectable stage III non-small cell lung cancer.

Authors:  Kyoichi Kaira; Noboru Oriuchi; Hisao Imai; Kimihiro Shimizu; Noriko Yanagitani; Noriaki Sunaga; Takeshi Hisada; Osamu Kawashima; Yosuke Kamide; Tamotsu Ishizuka; Yoshikatsu Kanai; Takashi Nakajima; Masatomo Mori
Journal:  Exp Ther Med       Date:  2010-07-20       Impact factor: 2.447

5.  Divergent expression of L-type amino acid transporter 1 during uterine cervical carcinogenesis.

Authors:  Kaname Uno; Haruki Kuwabara; Yuichi Terado; Kaoruko Kojima; Tomohiro Kawakami; Hiroshi Kamma; Hiroyuki Sakurai; Atsuhiko Sakamoto; Atsushi Kurata
Journal:  Hum Pathol       Date:  2011-04-29       Impact factor: 3.466

6.  High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions.

Authors:  Masaaki Ichinoe; Tetuo Mikami; Tsutomu Yoshida; Ikuyo Igawa; Tomoko Tsuruta; Norihiro Nakada; Naohiko Anzai; Yoshiyuki Suzuki; Hitoshi Endou; Isao Okayasu
Journal:  Pathol Int       Date:  2011-03-17       Impact factor: 2.534

7.  LAT1 regulates growth of uterine leiomyoma smooth muscle cells.

Authors:  John S Coon; Emily Su; Elizabeth Kerry Pearson; Hiroshi Ishikawa; Serdar E Bulun
Journal:  Reprod Sci       Date:  2010-07-02       Impact factor: 3.060

8.  Downregulation of LAT1 expression suppresses cholangiocarcinoma cell invasion and migration.

Authors:  Keatdamrong Janpipatkul; Kanoknetr Suksen; Suparerk Borwornpinyo; Natee Jearawiriyapaisarn; Suradej Hongeng; Pawinee Piyachaturawat; Arthit Chairoungdua
Journal:  Cell Signal       Date:  2014-04-13       Impact factor: 4.315

9.  Potential Biomarker of L-type Amino Acid Transporter 1 in Breast Cancer Progression.

Authors:  Zhongxing Liang; Heidi T Cho; Larry Williams; Aizhi Zhu; Ke Liang; Ke Huang; Hui Wu; Chunsu Jiang; Samuel Hong; Ronald Crowe; Mark M Goodman; Hyunsuk Shim
Journal:  Nucl Med Mol Imaging       Date:  2010-11-24

10.  Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer.

Authors:  Kyoichi Kaira; Yutaka Sunose; Yasuhiro Ohshima; Noriko S Ishioka; Kazuhisa Arakawa; Tetsushi Ogawa; Noriaki Sunaga; Kimihiro Shimizu; Hideyuki Tominaga; Noboru Oriuchi; Hideaki Itoh; Shushi Nagamori; Yoshikatsu Kanai; Aiko Yamaguchi; Atsuki Segawa; Munenori Ide; Masatomo Mori; Tetsunari Oyama; Izumi Takeyoshi
Journal:  BMC Cancer       Date:  2013-10-16       Impact factor: 4.430
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  17 in total

1.  Improved Radiosynthesis and Biological Evaluations of L- and D-1-[18F]Fluoroethyl-Tryptophan for PET Imaging of IDO-Mediated Kynurenine Pathway of Tryptophan Metabolism.

Authors:  Yangchun Xin; Hancheng Cai
Journal:  Mol Imaging Biol       Date:  2017-08       Impact factor: 3.488

2.  Dynamic 18F-FET PET is a powerful imaging biomarker in gadolinium-negative gliomas.

Authors:  Mathias Kunz; Nathalie Lisa Albert; Marcus Unterrainer; Christian la Fougere; Rupert Egensperger; Ulrich Schüller; Juergen Lutz; Simone Kreth; Jörg-Christian Tonn; Friedrich-Wilhelm Kreth; Niklas Thon
Journal:  Neuro Oncol       Date:  2019-02-14       Impact factor: 12.300

3.  Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.

Authors:  David Dickens; George N Chiduza; Gareth S A Wright; Munir Pirmohamed; Svetlana V Antonyuk; S Samar Hasnain
Journal:  Sci Rep       Date:  2017-03-08       Impact factor: 4.379

4.  A side-by-side evaluation of [18F]FDOPA enantiomers for non-invasive detection of neuroendocrine tumors by positron emission tomography.

Authors:  Athira Narayan; Yu Yan; Ala Lisok; Mary Brummet; Martin G Pomper; Wojciech G Lesniak; Robert F Dannals; Vanessa F Merino; Babak Behnam Azad
Journal:  Oncotarget       Date:  2019-10-08

Review 5.  Intricacies of the Molecular Machinery of Catecholamine Biosynthesis and Secretion by Chromaffin Cells of the Normal Adrenal Medulla and in Pheochromocytoma and Paraganglioma.

Authors:  Annika M A Berends; Graeme Eisenhofer; Lauren Fishbein; Anouk N A V D Horst-Schrivers; Ido P Kema; Thera P Links; Jacques W M Lenders; Michiel N Kerstens
Journal:  Cancers (Basel)       Date:  2019-08-06       Impact factor: 6.639

6.  LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM.

Authors:  George N Chiduza; Rachel M Johnson; Gareth S A Wright; Svetlana V Antonyuk; Stephen P Muench; S Samar Hasnain
Journal:  Acta Crystallogr D Struct Biol       Date:  2019-06-28       Impact factor: 7.652

Review 7.  Drug and Solute Transporters in Mediating Resistance to Novel Therapeutics in Multiple Myeloma.

Authors:  Rachel L Mynott; Craig T Wallington-Beddoe
Journal:  ACS Pharmacol Transl Sci       Date:  2021-04-15

8.  Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells.

Authors:  Florence Polet; Ruben Martherus; Cyril Corbet; Adan Pinto; Olivier Feron
Journal:  Oncotarget       Date:  2016-07-19

Review 9.  L-Type amino acid transporter 1 as a target for drug delivery.

Authors:  Elena Puris; Mikko Gynther; Seppo Auriola; Kristiina M Huttunen
Journal:  Pharm Res       Date:  2020-05-06       Impact factor: 4.200

Review 10.  New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer.

Authors:  Deborah Agostini; Valentina Natalucci; Giulia Baldelli; Mauro De Santi; Sabrina Donati Zeppa; Luciana Vallorani; Giosuè Annibalini; Francesco Lucertini; Ario Federici; Riccardo Izzo; Vilberto Stocchi; Elena Barbieri
Journal:  Oxid Med Cell Longev       Date:  2018-09-30       Impact factor: 6.543
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