Rachel M Radin1,2, Lauren B Shomaker1,3, Nichole R Kelly1,2,3, Courtney K Pickworth1, Katherine A Thompson1, Sheila M Brady1, Andrew Demidowich1, Ovidiu Galescu1, Anne M Altschul1, Lisa M Shank1,2, Susan Z Yanovski1,4, Marian Tanofsky-Kraff1,2, Jack A Yanovski1. 1. Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH), DHHS, Bethesda, Maryland, 20892, USA. 2. Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. 3. Department of Human Development and Family Studies, Colorado State University, Fort Collins, Colorado, 80523, USA. 4. Office of Obesity Research, Division of Digestive Diseases and Nutrition, National Institute of Diabetes, Digestive, and Kidney Disorders, NIH, DHHS, Bethesda, Maryland, 20892, USA.
Abstract
BACKGROUND:Adults with binge eating disorder may have an exaggerated or blunted cortisol response to stress. Yet, limited data exist among youth who report loss of control (LOC) eating, a developmental precursor to binge eating disorder. METHODS: We studied cortisol reactivity among 178 healthy adolescents with and without LOC eating. Following a buffet lunch meal adolescents were randomly assigned to watch a neutral or sad film clip. After, they were offered snacks from a multi-item array to assess eating in the absence of hunger. Salivary cortisol was collected at -80, 0, 30 and 50 min relative to film administration, and state mood ratings were reported before and after the film. RESULTS:Adolescents with LOC had greater increases in negative affect during the experimental paradigm in both conditions (ps > 0.05). Depressive symptoms, but not LOC, related to a greater cortisol response in the sad film condition (ps > 0.05). Depressive symptoms and state LOC were related to different aspects of eating behaviour, independent of film condition or cortisol response (ps > 0.05). CONCLUSIONS: A film clip that induced depressed state affect increased salivary cortisol only in adolescents with more elevated depressive symptoms. Adolescents with and without LOC were differentiated by greater increases in state depressed affect during laboratory test meals but had no difference in cortisol reactivity. Future studies are required to determine if adolescents with LOC manifest alterations in stress reactivity to alternative stress-inducing situations.
RCT Entities:
BACKGROUND: Adults with binge eating disorder may have an exaggerated or blunted cortisol response to stress. Yet, limited data exist among youth who report loss of control (LOC) eating, a developmental precursor to binge eating disorder. METHODS: We studied cortisol reactivity among 178 healthy adolescents with and without LOC eating. Following a buffet lunch meal adolescents were randomly assigned to watch a neutral or sad film clip. After, they were offered snacks from a multi-item array to assess eating in the absence of hunger. Salivary cortisol was collected at -80, 0, 30 and 50 min relative to film administration, and state mood ratings were reported before and after the film. RESULTS: Adolescents with LOC had greater increases in negative affect during the experimental paradigm in both conditions (ps > 0.05). Depressive symptoms, but not LOC, related to a greater cortisol response in the sad film condition (ps > 0.05). Depressive symptoms and state LOC were related to different aspects of eating behaviour, independent of film condition or cortisol response (ps > 0.05). CONCLUSIONS: A film clip that induced depressed state affect increased salivary cortisol only in adolescents with more elevated depressive symptoms. Adolescents with and without LOC were differentiated by greater increases in state depressed affect during laboratory test meals but had no difference in cortisol reactivity. Future studies are required to determine if adolescents with LOC manifest alterations in stress reactivity to alternative stress-inducing situations.
Authors: Marian Tanofsky-Kraff; Lauren B Shomaker; Cara Olsen; Caroline A Roza; Laura E Wolkoff; Kelli M Columbo; Gina Raciti; Jaclyn M Zocca; Denise E Wilfley; Susan Z Yanovski; Jack A Yanovski Journal: J Abnorm Psychol Date: 2011-02
Authors: M Tanofsky-Kraff; L B Shomaker; E A Stern; R Miller; N Sebring; D Dellavalle; S Z Yanovski; V S Hubbard; J A Yanovski Journal: Int J Obes (Lond) Date: 2012-01-10 Impact factor: 5.095
Authors: Laura R Stroud; Elizabeth Foster; George D Papandonatos; Kathryn Handwerger; Douglas A Granger; Katie T Kivlighan; Raymond Niaura Journal: Dev Psychopathol Date: 2009
Authors: Carolina Lo Sauro; Claudia Ravaldi; Pier Luigi Cabras; Carlo Faravelli; Valdo Ricca Journal: Neuropsychobiology Date: 2008-06-13 Impact factor: 2.328
Authors: Lauren B Shomaker; Marian Tanofsky-Kraff; Elizabeth A Stern; Rachel Miller; Jaclyn M Zocca; Sara E Field; Susan Z Yanovski; Van S Hubbard; Jack A Yanovski Journal: Diabetes Care Date: 2011-09-12 Impact factor: 19.112