C S Betz1, M Kraft2, C Arens3, M Schuster4, C Pfeffer4, A Rühm5, H Stepp5, A Englhard4, V Volgger4. 1. Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland. christian.betz@med.uni-muenchen.de. 2. Klinik für Hals-, Nasen- und Ohrenheilkunde, Hals- und Gesichtschirurgie, Kantonsspital Baselland, Liestal, Schweiz. 3. Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Magdeburg A.ö.R., Magdeburg, Deutschland. 4. Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland. 5. Laser-Forschungslabor am LIFE-Zentrum, Klinikum der Universität München, München, Deutschland.
Abstract
BACKGROUND: Optical diagnostic methods may simplify and improve the early diagnosis of tumours of the upper aerodigestive tract; however, these have not yet found their way into clinical routine. OBJECTIVE: This article aims to define the problems that have prevented routine use of optical diagnostic methods so far, as well as listing and also explaining potential trendsetting approaches to overcome these difficulties. MATERIALS AND METHODS: The study is based on a combined analysis of publically accessible databases (PubMed MEDLINE, Thompson Reuters Web of Science, SPIE. Digital Library; full time period available; search strings: "oral cavity", "pharynx", "larnyx", "optical diagnosis", "optical biopsy", "optical coherence tomography", "confocal endomicroscopy", "fluorescence endoscopy", "narrow band imaging", "non-linear imaging", "fluorescence lifetime imaging"), as well as personal experiences. RESULTS: Both conceptual and methodical problems were determined, and possible solutions based on current developments are discussed. CONCLUSION: Optical diagnostic methods have the potential to revolutionise early diagnosis of upper aerodigestive tract malignancies, providing the different hurdles listed in this review can be overcome.
BACKGROUND: Optical diagnostic methods may simplify and improve the early diagnosis of tumours of the upper aerodigestive tract; however, these have not yet found their way into clinical routine. OBJECTIVE: This article aims to define the problems that have prevented routine use of optical diagnostic methods so far, as well as listing and also explaining potential trendsetting approaches to overcome these difficulties. MATERIALS AND METHODS: The study is based on a combined analysis of publically accessible databases (PubMed MEDLINE, Thompson Reuters Web of Science, SPIE. Digital Library; full time period available; search strings: "oral cavity", "pharynx", "larnyx", "optical diagnosis", "optical biopsy", "optical coherence tomography", "confocal endomicroscopy", "fluorescence endoscopy", "narrow band imaging", "non-linear imaging", "fluorescence lifetime imaging"), as well as personal experiences. RESULTS: Both conceptual and methodical problems were determined, and possible solutions based on current developments are discussed. CONCLUSION: Optical diagnostic methods have the potential to revolutionise early diagnosis of upper aerodigestive tract malignancies, providing the different hurdles listed in this review can be overcome.
Authors: Veronika Volgger; Susanne Girschick; Stephan Ihrler; Anna Sophie Englhard; Herbert Stepp; Christian Stephan Betz Journal: Head Neck Date: 2015-11-28 Impact factor: 3.147
Authors: Jakob Unger; Jörg Lohscheller; Maximilian Reiter; Katharina Eder; Christian S Betz; Maria Schuster Journal: Cancer Res Date: 2014-11-04 Impact factor: 12.701
Authors: M Goncalves; M Aubreville; S K Mueller; M Sievert; A Maier; H Iro; C Bohr Journal: Acta Otorhinolaryngol Ital Date: 2019-01-31 Impact factor: 2.124
Authors: Matti Sievert; Florian Stelzle; Marc Aubreville; Sarina K Mueller; Markus Eckstein; Nicolai Oetter; Andreas Maier; Konstantinos Mantsopoulos; Heinrich Iro; Miguel Goncalves Journal: Eur Arch Otorhinolaryngol Date: 2021-02-13 Impact factor: 2.503