Haruko Takeuchi1, Al Fazal Khan2, Mohammad Yunus3, Mohammad Imrul Hasan2, Mohammad Delwer Hossain Hawlader4, Sayaka Takanashi5, Hirotsugu Kano6, Khalequz Zaman3, Hafizur R Chowdhury7, Yukiko Wagatsuma8, Shinji Nakahara9, Tsutomu Iwata10. 1. Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: htakeuchi-tky@umin.net. 2. Centre for Food and Nutrition Security, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. 3. Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. 4. Department of Epidemiology, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh. 5. Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 6. Department of Pediatrics, Teikyo University School of Medicine University Hospital, Kanagawa, Japan. 7. Centre for Global Burden of Disease, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. 8. Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. 9. Department of Liberal Arts and Human Development, Kanagawa University of Human Services, Kanagawa, Japan. 10. Department of Education for Childcare, Faculty of Child Studies, Tokyo Kasei University, Saitama, Japan.
Abstract
BACKGROUND: Studies have addressed the immunomodulatory effects of helminths and their protective effects upon asthma. However, anti-Ascaris IgE has been reported to be associated with an increased risk of asthma symptoms. We examined the association between serum levels of anti-Ascaris IgE and bronchial hyper-responsiveness (BHR) in children living in rural Bangladesh. METHODS: Serum anti-Ascaris IgE level was measured and the BHR test done in 158 children aged 9 years selected randomly from a general population of 1705 in the Matlab Health and Demographic Surveillance Area of the International Centre for Diarrhoeal Disease Research, Bangladesh. We investigated wheezing symptoms using a questionnaire from the International Study of Asthma and Allergies in Childhood. BHR tests were successfully done on 152 children (108 'current wheezers'; 44 'never-wheezers'). We examined the association between anti-Ascaris IgE level and wheezing and BHR using multiple logistic regression analyses. RESULTS: Of 108 current-wheezers, 59 were BHR-positive; of 44 never-wheezers, 32 were BHR-negative. Mean anti-Ascaris IgE levels were significantly higher (12.51 UA/ml; 95% confidence interval (CI), 9.21-17.00) in children with current wheezing with BHR-positive than in those of never-wheezers with BHR-negative (3.89; 2.65-5.70; t test, p < 0.001). A BHR-positive test was independently associated with anti-Ascaris IgE levels with an odds ratio (OR) = 7.30 [95% CI, 2.28-23.33], p = 0.001 when adjusted for total IgE, anti-Dermatophagoides pteronyssinus IgE, pneumonia history, parental asthma, Trichuris infection, forced expiratory volume in one second, eosinophilic leukocyte count, and sex. CONCLUSIONS: Anti-Ascaris IgE level is associated with an increased risk of BHR among 9-year-old rural Bangladeshi children.
BACKGROUND: Studies have addressed the immunomodulatory effects of helminths and their protective effects upon asthma. However, anti-Ascaris IgE has been reported to be associated with an increased risk of asthma symptoms. We examined the association between serum levels of anti-Ascaris IgE and bronchial hyper-responsiveness (BHR) in children living in rural Bangladesh. METHODS: Serum anti-Ascaris IgE level was measured and the BHR test done in 158 children aged 9 years selected randomly from a general population of 1705 in the Matlab Health and Demographic Surveillance Area of the International Centre for Diarrhoeal Disease Research, Bangladesh. We investigated wheezing symptoms using a questionnaire from the International Study of Asthma and Allergies in Childhood. BHR tests were successfully done on 152 children (108 'current wheezers'; 44 'never-wheezers'). We examined the association between anti-Ascaris IgE level and wheezing and BHR using multiple logistic regression analyses. RESULTS: Of 108 current-wheezers, 59 were BHR-positive; of 44 never-wheezers, 32 were BHR-negative. Mean anti-Ascaris IgE levels were significantly higher (12.51 UA/ml; 95% confidence interval (CI), 9.21-17.00) in children with current wheezing with BHR-positive than in those of never-wheezers with BHR-negative (3.89; 2.65-5.70; t test, p < 0.001). A BHR-positive test was independently associated with anti-Ascaris IgE levels with an odds ratio (OR) = 7.30 [95% CI, 2.28-23.33], p = 0.001 when adjusted for total IgE, anti-Dermatophagoides pteronyssinus IgE, pneumonia history, parental asthma, Trichuris infection, forced expiratory volume in one second, eosinophilic leukocyte count, and sex. CONCLUSIONS: Anti-Ascaris IgE level is associated with an increased risk of BHR among 9-year-old rural Bangladeshi children.
Authors: Jill E Weatherhead; Paul Porter; Amy Coffey; Dana Haydel; Leroy Versteeg; Bin Zhan; Ana Clara Gazzinelli Guimarães; Ricardo Fujiwara; Ana M Jaramillo; Maria Elena Bottazzi; Peter J Hotez; David B Corry; Coreen M Beaumier Journal: Infect Immun Date: 2018-11-20 Impact factor: 3.441