Masanari Watanabe1, Hisashi Noma2, Jun Kurai3, Hiroyuki Sano4, Masaaki Mikami5, Hiroyuki Yamamoto6, Yasuto Ueda3, Hirokazu Touge3, Yoshihiro Fujii7, Toshikazu Ikeda8, Hirokazu Tokuyasu9, Tatsuya Konishi10, Akira Yamasaki3, Tadashi Igishi3, Eiji Shimizu3. 1. Department of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine, Tottori, Japan. Electronic address: watanabm@grape.med.tottori-u.ac.jp. 2. Department of Data Science, The Institute of Statistical Mathematics, Tokyo, Japan. 3. Department of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine, Tottori, Japan. 4. Department of Respiratory Medicine and Allergology, Kinki University Faculty of Medicine, Osaka, Japan. 5. Hosshoji Clinic, Tottori, Japan. 6. Saihaku Hospital, Tottori, Japan. 7. Sakaiminato Hospital, Tottori, Japan. 8. Matsue National Hospital, Shimane, Japan. 9. Department of Respiratory Medicine, Matsue Red Cross Hospital, Shimane, Japan. 10. Department of Respiratory Medicine, Matsue City Hospital, Shimane, Japan.
Abstract
BACKGROUND: Asian dust (AD) has become a major health concern. The concentration of AD is typically expressed in particulate matter less than 10 μm (PM10) and 2.5 μm (PM2.5). However, PM10 and PM2.5 consist of various substances besides AD. Light detection and ranging (LIDAR) systems can selectively measure the quantity of AD particles to distinguish non-spherical airborne particles from spherical airborne particles. The objective of this study was to investigate the relationship between pulmonary function in adult asthma patients and AD using LIDAR data. METHODS: Subjects were 231 adult asthma patients who had their morning peak expiratory flow (PEF) measured from March to May 2012. A linear mixed model was used to estimate the association of PEF with sand dust particles detected by LIDAR. RESULTS: Increases in the interquartile range of AD particles (0.018 km(-1)) led to changes in PEF of -0.42 L/min (95% confidence interval [CI], -0.85 to 0.01). An increase of 11.8 μg/m(3) in suspended particulate matter and 6.9 μg/m(3) in PM2.5 led to decreases of -0.17 L/min (-0.53 to 0.21) and 0.03 L/min (-0.35 to 0.42), respectively. A heavy AD day was defined as a day with a level of AD particles >0.032 km(-1), which was the average plus one standard deviation during the study period, and six heavy AD days were identified. Change in PEF after a heavy AD day was -0.97 L/min (-1.90 to -0.04). CONCLUSIONS: Heavy exposure to AD particles was significantly associated with decreased pulmonary function in adult asthma patients.
BACKGROUND: Asian dust (AD) has become a major health concern. The concentration of AD is typically expressed in particulate matter less than 10 μm (PM10) and 2.5 μm (PM2.5). However, PM10 and PM2.5 consist of various substances besides AD. Light detection and ranging (LIDAR) systems can selectively measure the quantity of AD particles to distinguish non-spherical airborne particles from spherical airborne particles. The objective of this study was to investigate the relationship between pulmonary function in adult asthmapatients and AD using LIDAR data. METHODS: Subjects were 231 adult asthmapatients who had their morning peak expiratory flow (PEF) measured from March to May 2012. A linear mixed model was used to estimate the association of PEF with sand dust particles detected by LIDAR. RESULTS: Increases in the interquartile range of AD particles (0.018 km(-1)) led to changes in PEF of -0.42 L/min (95% confidence interval [CI], -0.85 to 0.01). An increase of 11.8 μg/m(3) in suspended particulate matter and 6.9 μg/m(3) in PM2.5 led to decreases of -0.17 L/min (-0.53 to 0.21) and 0.03 L/min (-0.35 to 0.42), respectively. A heavy AD day was defined as a day with a level of AD particles >0.032 km(-1), which was the average plus one standard deviation during the study period, and six heavy AD days were identified. Change in PEF after a heavy AD day was -0.97 L/min (-1.90 to -0.04). CONCLUSIONS: Heavy exposure to AD particles was significantly associated with decreased pulmonary function in adult asthmapatients.
Authors: Hong Jo Kim; Jin Yong Song; Tae Il Park; Won Seok Choi; Jong Heon Kim; Oh Seong Kwon; Ji-Yun Lee Journal: Arch Pharm Res Date: 2022-01-04 Impact factor: 6.010