Literature DB >> 26662800

The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization.

Changming Wang1, Zunqi Hu1, Zhenxin Zhu1, Xin Zhang1, Ziran Wei1, Yu Zhang1, Dali Hu2, Qingping Cai3.   

Abstract

Macrophages play crucial roles in promoting tumor development and progression. In the present study, we found that the mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) was efficient in inducing M1 macrophage polarization. PA-MSHA treatment increases expression of M1-related cytokines and promotes activation of murine peritoneal macrophages (MPM). Interestingly, PA-MSHA inhibits cell proliferation and migration and induces the apoptosis of gastric carcinoma cells. These effects of PA-MSHA on M1 polarization were associated with activation of NF-κB expression. Thus, inducing polarization of M1 by PA-MSHA may be one potential strategy for inhibiting gastric carcinoma progression in mice.

Entities:  

Keywords:  Gastric carcinoma; M1 polarization; NF-κB; PA-MSHA

Mesh：

Substances：

Year:  2015        PMID： 26662800     DOI： 10.1007/s13277-015-4451-6

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  23 in total

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  9 in total

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