Literature DB >> 26661149

The influence of gender on 'tissue at risk' in acute stroke: A diffusion-weighted magnetic resonance imaging study in a rat model of focal cerebral ischaemia.

Tracey A Baskerville1, I Mhairi Macrae2, William M Holmes1, Christopher McCabe1.   

Abstract

This is the first study to assess the influence of sex on the evolution of ischaemic injury and penumbra. Permanent middle cerebral artery occlusion was induced in male (n = 9) and female (n = 10) Sprague-Dawley rats. Diffusion-weighted imaging was acquired over 4 h and infarct determined from T2 images at 24 h post-permanent middle cerebral artery occlusion. Penumbra was determined retrospectively from serial apparent diffusion coefficient lesions and T2-defined infarct. Apparent diffusion coefficient lesion volume was significantly smaller in females from 0.5 to 4 h post permanent middle cerebral artery occlusion as was infarct volume. Penumbral volume, and its loss over time, was not significantly different despite the sex difference in acute and final lesion volumes.
© The Author(s) 2015.

Entities:  

Keywords:  Acute stroke; MCAO; diffusion-weighted MRI; gender

Mesh：

Year:  2015        PMID： 26661149      PMCID： PMC4759665          DOI： 10.1177/0271678X15606137

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  16 in total

1.  Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods.

Authors:  Emma Reid; Delyth Graham; M Rosario Lopez-Gonzalez; William M Holmes; I Mhairi Macrae; Christopher McCabe
Journal:  J Cereb Blood Flow Metab       Date:  2012-06-06       Impact factor: 6.200

Review 2.  Estrogen and stroke: a balanced analysis.

Authors:  Patricia D Hurn; Lawrence M Brass
Journal:  Stroke       Date:  2003-02       Impact factor: 7.914

Review 3.  Estrogen as a neuroprotectant in stroke.

Authors:  P D Hurn; I M Macrae
Journal:  J Cereb Blood Flow Metab       Date:  2000-04       Impact factor: 6.200

4.  Female mice liberated for inclusion in neuroscience and biomedical research.

Authors:  Brian J Prendergast; Kenneth G Onishi; Irving Zucker
Journal:  Neurosci Biobehav Rev       Date:  2014-01-20       Impact factor: 8.989

5.  Thresholds in cerebral ischemia - the ischemic penumbra.

Authors:  J Astrup; B K Siesjö; L Symon
Journal:  Stroke       Date:  1981 Nov-Dec       Impact factor: 7.914

6.  Expanding the window for thrombolytic therapy in acute stroke. The potential role of acute MRI for patient selection.

Authors:  G W Albers
Journal:  Stroke       Date:  1999-10       Impact factor: 7.914

7.  Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging.

Authors:  T Gerriets; E Stolz; M Walberer; C Müller; A Kluge; A Bachmann; M Fisher; M Kaps; G Bachmann
Journal:  Stroke       Date:  2004-01-22       Impact factor: 7.914

8.  Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia.

Authors:  Xiangjun Meng; Marc Fisher; Qiang Shen; Christopher H Sotak; Timothy Q Duong
Journal:  Ann Neurol       Date:  2004-02       Impact factor: 10.422

9.  Reversible middle cerebral artery occlusion without craniectomy in rats.

Authors:  E Z Longa; P R Weinstein; S Carlson; R Cummins
Journal:  Stroke       Date:  1989-01       Impact factor: 7.914

10.  Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion.

Authors:  Craig A Robertson; Christopher McCabe; Lindsay Gallagher; Maria del Rosario Lopez-Gonzalez; William M Holmes; Barrie Condon; Keith W Muir; Celestine Santosh; I Mhairi Macrae
Journal:  J Cereb Blood Flow Metab       Date:  2011-05-11       Impact factor: 6.200
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  5 in total

1.  Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area.

Authors:  Luc Bertrand; Levi Dygert; Michal Toborek
Journal:  J Vis Exp       Date:  2017-02-02       Impact factor: 1.355

2.  Sex Differences in the Cerebral Collateral Circulation.

Authors:  James E Faber; Scott M Moore; Jennifer L Lucitti; Amir Aghajanian; Hua Zhang
Journal:  Transl Stroke Res       Date:  2016-11-14       Impact factor: 6.829

3.  3,6'- and 1,6'-Dithiopomalidomide Mitigate Ischemic Stroke in Rats and Blunt Inflammation.

Authors:  Yan-Rou Tsai; Dong Seok Kim; Shih-Chang Hsueh; Kai-Yun Chen; John Chung-Che Wu; Jia-Yi Wang; Yi-Syue Tsou; Inho Hwang; Yukyung Kim; Dayeon Gil; Eui Jung Jo; Baek-Soo Han; David Tweedie; Daniela Lecca; Michael T Scerba; Warren R Selman; Barry J Hoffer; Nigel H Greig; Yung-Hsiao Chiang
Journal:  Pharmaceutics       Date:  2022-04-27       Impact factor: 6.525

Review 4.  Therapeutic potential of the renin angiotensin system in ischaemic stroke.

Authors:  Mariana Moreira Coutinho Arroja; Emma Reid; Christopher McCabe
Journal:  Exp Transl Stroke Med       Date:  2016-10-07

5.  Proof of concept and feasibility studies examining the influence of combination ribose, adenine and allopurinol treatment on stroke outcome in the rat.

Authors:  Kiterie M E Faller; Joshua Leach; Pamela Johnston; William M Holmes; I Mhairi Macrae; Bruno G Frenguelli
Journal:  Brain Neurosci Adv       Date:  2017-07-13
  5 in total

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