H Xu1, S Ma1, F-Y Tang2, Y Chen1, H Zhou2, M Chen2, B Wang3, X Liu3, X Xie4. 1. Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China. 2. Department of Nephrology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China. 3. Department of Clinical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China. 4. Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China. xie_xiongwei@163.com.
Abstract
BACKGROUND: We investigated the association between five selected single-nucleotide polymorphisms (rs12933505, rs3180279, rs3794264, rs4673, rs1049255) in the NAD(P)H p22phox gene and acute myocardial infarction (AMI) as well as severity of coronary artery stenosis in a Han Chinese population. PATIENTS AND METHODS: A total of 168 patients with AMI and 138 healthy controls were recruited. The TaqMan allelic discrimination assay was used to genotype five single-nucleotide polymorphisms. RESULTS: The frequency of the rs1049255 G allele was significantly lower in patients with AMI than in controls (p = 0.022). Compared with subjects with an AA genotype, subjects with a GG or AG genotype had a lower risk of AMI [multivariate-adjusted odds ratio (OR), 0.53; 95 % CI, 0.29-0.95; p = 0.031). Subjects with the GG and AG genotypes of rs1049255 showed a decreased susceptibility for triple-vessel disease (TVD) as compared with controls (multivariate-adjusted OR, 0.43; 95 % CI, 0.19-0.98; p = 0.042). Multiple logistic regression analysis revealed that the rs1049255G variant was an independent protective factor for AMI/TVD. CONCLUSION: The results suggest there is an association between the p22phox rs1049255 polymorphism with the prevalence of AMI and the severity of coronary artery stenosis in the Han Chinese population.
BACKGROUND: We investigated the association between five selected single-nucleotide polymorphisms (rs12933505, rs3180279, rs3794264, rs4673, rs1049255) in the NAD(P)Hp22phox gene and acute myocardial infarction (AMI) as well as severity of coronary artery stenosis in a Han Chinese population. PATIENTS AND METHODS: A total of 168 patients with AMI and 138 healthy controls were recruited. The TaqMan allelic discrimination assay was used to genotype five single-nucleotide polymorphisms. RESULTS: The frequency of the rs1049255 G allele was significantly lower in patients with AMI than in controls (p = 0.022). Compared with subjects with an AA genotype, subjects with a GG or AG genotype had a lower risk of AMI [multivariate-adjusted odds ratio (OR), 0.53; 95 % CI, 0.29-0.95; p = 0.031). Subjects with the GG and AG genotypes of rs1049255 showed a decreased susceptibility for triple-vessel disease (TVD) as compared with controls (multivariate-adjusted OR, 0.43; 95 % CI, 0.19-0.98; p = 0.042). Multiple logistic regression analysis revealed that the rs1049255G variant was an independent protective factor for AMI/TVD. CONCLUSION: The results suggest there is an association between the p22phoxrs1049255 polymorphism with the prevalence of AMI and the severity of coronary artery stenosis in the Han Chinese population.
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