Y Liu1, C Lukas2, M D Steenwijk3, M Daams4, A Versteeg3, Y Duan5, K Li5, F Weiler6, H K Hahn6, M P Wattjes3, F Barkhof3, H Vrenken7. 1. From the Department of Radiology (Y.L., Y.D., K.L.), Xuanwu Hospital, Capital Medical University, Beijing, P.R. China Department of Radiology and Nuclear Medicine (Y.L., M.D.S., M.D., A.V., M.P.W., F.B., H.V.), Neuroscience Campus Amsterdam Department of Neurology and Tianjin Neurological Institute (Y.L.), Tianjin Medical University, General Hospital, Tianjin, P.R. China asiaeurope80@gmail.com. 2. Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.L.), St. Josef Hospital, Ruhr University, Bochum, Germany. 3. Department of Radiology and Nuclear Medicine (Y.L., M.D.S., M.D., A.V., M.P.W., F.B., H.V.), Neuroscience Campus Amsterdam. 4. Department of Radiology and Nuclear Medicine (Y.L., M.D.S., M.D., A.V., M.P.W., F.B., H.V.), Neuroscience Campus Amsterdam Department of Anatomy and Neurosciences (M.D.), Section of Clinical Neuroscience. 5. From the Department of Radiology (Y.L., Y.D., K.L.), Xuanwu Hospital, Capital Medical University, Beijing, P.R. China. 6. Fraunhofer MEVIS, Institute for Medical Image Computing (F.W., H.K.H.), Bremen, Germany. 7. Department of Radiology and Nuclear Medicine (Y.L., M.D.S., M.D., A.V., M.P.W., F.B., H.V.), Neuroscience Campus Amsterdam Department of Physics and Medical Technology (H.V.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.
Abstract
BACKGROUND AND PURPOSE: Spinal cord atrophy is a common and clinically relevant characteristic in multiple sclerosis. We aimed to perform a multicenter validation study of mean upper cervical cord area measurements in patients with multiple sclerosis and healthy controls from head MR images and to explore the effect of gadolinium administration on mean upper cervical cord area measurements. MATERIALS AND METHODS: We recruited 97 subjects from 3 centers, including 60 patients with multiple sclerosis of different disease types and 37 healthy controls. Both cervical cord and head 3D T1-weighted images were acquired. In 11 additional patients from 1 center, head images before and after gadolinium administration and cervical cord images after gadolinium administration were acquired. The mean upper cervical cord area was compared between cervical cord and head images by using intraclass correlation coefficients (ICC) for both consistency (ICCconsist) and absolute (ICCabs) agreement. RESULTS: There was excellent agreement of mean upper cervical cord area measurements from head and cervical cord images in the entire group (ICCabs = 0.987) and across centers and disease subtypes. The mean absolute difference between the mean upper cervical cord area measured from head and cervical cord images was 2 mm(2) (2.3%). Additionally, excellent agreement was found between the mean upper cervical cord area measured from head images with and without gadolinium administration (ICCabs = 0.991) and between the cervical cord and head images with gadolinium administration (ICCabs = 0.992). CONCLUSIONS: Excellent agreement between mean upper cervical cord area measurements on head and cervical cord images was observed in this multicenter study, implying that upper cervical cord atrophy can be reliably measured from head images. Postgadolinium head or cervical cord images may also be suitable for measuring mean upper cervical cord area.
BACKGROUND AND PURPOSE:Spinal cord atrophy is a common and clinically relevant characteristic in multiple sclerosis. We aimed to perform a multicenter validation study of mean upper cervical cord area measurements in patients with multiple sclerosis and healthy controls from head MR images and to explore the effect of gadolinium administration on mean upper cervical cord area measurements. MATERIALS AND METHODS: We recruited 97 subjects from 3 centers, including 60 patients with multiple sclerosis of different disease types and 37 healthy controls. Both cervical cord and head 3D T1-weighted images were acquired. In 11 additional patients from 1 center, head images before and after gadolinium administration and cervical cord images after gadolinium administration were acquired. The mean upper cervical cord area was compared between cervical cord and head images by using intraclass correlation coefficients (ICC) for both consistency (ICCconsist) and absolute (ICCabs) agreement. RESULTS: There was excellent agreement of mean upper cervical cord area measurements from head and cervical cord images in the entire group (ICCabs = 0.987) and across centers and disease subtypes. The mean absolute difference between the mean upper cervical cord area measured from head and cervical cord images was 2 mm(2) (2.3%). Additionally, excellent agreement was found between the mean upper cervical cord area measured from head images with and without gadolinium administration (ICCabs = 0.991) and between the cervical cord and head images with gadolinium administration (ICCabs = 0.992). CONCLUSIONS: Excellent agreement between mean upper cervical cord area measurements on head and cervical cord images was observed in this multicenter study, implying that upper cervical cord atrophy can be reliably measured from head images. Postgadolinium head or cervical cord images may also be suitable for measuring mean upper cervical cord area.
Authors: Nico Papinutto; Rohit Bakshi; Antje Bischof; Peter A Calabresi; Eduardo Caverzasi; R Todd Constable; Esha Datta; Gina Kirkish; Govind Nair; Jiwon Oh; Daniel Pelletier; Dzung L Pham; Daniel S Reich; William Rooney; Snehashis Roy; Daniel Schwartz; Russell T Shinohara; Nancy L Sicotte; William A Stern; Ian Tagge; Shahamat Tauhid; Subhash Tummala; Roland G Henry Journal: Magn Reson Med Date: 2017-06-15 Impact factor: 4.668
Authors: Burcu Zeydan; Xinyi Gu; Elizabeth J Atkinson; B Mark Keegan; Brian G Weinshenker; Jan-Mendelt Tillema; Daniel Pelletier; Christina J Azevedo; Christine Lebrun-Frenay; Aksel Siva; Darin T Okuda; Kejal Kantarci; Orhun H Kantarci Journal: Neurol Neuroimmunol Neuroinflamm Date: 2018-01-22
Authors: Kamyar Taheri; Irene M Vavasour; Shawna Abel; Lisa Eunyoung Lee; Poljanka Johnson; Stephen Ristow; Roger Tam; Cornelia Laule; Nathalie Chantal Ackermans; Alice Schabas; Helen Cross; Jillian Katrina Chan; Ana-Luiza Sayao; Virender Bhan; Virginia Devonshire; Robert Carruthers; David Kb Li; Anthony L Traboulsee; Shannon H Kolind; Adam Vladimir Dvorak Journal: Mult Scler J Exp Transl Clin Date: 2022-01-07
Authors: Ingrid Anne Lie; Emma Kerklingh; Kristin Wesnes; David R van Nederpelt; Iman Brouwer; Øivind Torkildsen; Kjell-Morten Myhr; Frederik Barkhof; Lars Bø; Hugo Vrenken Journal: Eur Radiol Date: 2022-01-03 Impact factor: 7.034