Bernhard Baier1, Julian Conrad2, Thomas Stephan2, Valerie Kirsch2, Thomas Vogt2, Janine Wilting2, Wibke Müller-Forell2, Marianne Dieterich2. 1. From the Department of Neurology (B.B., T.V., J.W.) and the Institute of Neuroradiology (W.M.-F.), University Medical Centre of the Johannes Gutenberg University, Mainz; Edith-Stein Fachklinik (B.B.), Bad Bergzabern; the Department of Neurology and German Center for Vertigo and Balance Disorders-IFB (J.C., T.S., V.K., M.D.), Ludwig-Maximilians-University, Munich; and Munich Center for Systems Neurology (SyNergy) (M.D.), Germany. baierb@uni-mainz.de. 2. From the Department of Neurology (B.B., T.V., J.W.) and the Institute of Neuroradiology (W.M.-F.), University Medical Centre of the Johannes Gutenberg University, Mainz; Edith-Stein Fachklinik (B.B.), Bad Bergzabern; the Department of Neurology and German Center for Vertigo and Balance Disorders-IFB (J.C., T.S., V.K., M.D.), Ludwig-Maximilians-University, Munich; and Munich Center for Systems Neurology (SyNergy) (M.D.), Germany.
Abstract
OBJECTIVE: To determine whether there are distinct thalamic regions statistically associated with either contraversive or ipsiversive disturbance of verticality perception measured by subjective visual vertical (SVV). METHODS: We used modern statistical lesion behavior mapping on a sample of 37 stroke patients with isolated thalamic lesions to clarify which thalamic regions are involved in graviceptive otolith processing and whether there are distinct regions associated with contraversive or ipsiversive SVV deviation. RESULTS: We found 2 distinct systems of graviceptive processing within the thalamus. Contraversive tilt of SVV was associated with lesions to the nuclei dorsomedialis, intralamellaris, centrales thalami, posterior thalami, ventrooralis internus, ventrointermedii, ventrocaudales and superior parts of the nuclei parafascicularis thalami. The regions associated with ipsiversive tilt of SVV were located in more inferior regions, involving structures such as the nuclei endymalis thalami, inferior parts of the nuclei parafascicularis thalami, and also small parts of the junction zone of the nuclei ruber tegmenti and brachium conjunctivum. CONCLUSIONS: Our data indicate that there are 2 anatomically distinct graviceptive signal processing mechanisms within the vestibular network in humans that lead, when damaged, to a vestibular tone imbalance either to the contraversive or to the ipsiversive side.
OBJECTIVE: To determine whether there are distinct thalamic regions statistically associated with either contraversive or ipsiversive disturbance of verticality perception measured by subjective visual vertical (SVV). METHODS: We used modern statistical lesion behavior mapping on a sample of 37 strokepatients with isolated thalamic lesions to clarify which thalamic regions are involved in graviceptive otolith processing and whether there are distinct regions associated with contraversive or ipsiversive SVV deviation. RESULTS: We found 2 distinct systems of graviceptive processing within the thalamus. Contraversive tilt of SVV was associated with lesions to the nuclei dorsomedialis, intralamellaris, centrales thalami, posterior thalami, ventrooralis internus, ventrointermedii, ventrocaudales and superior parts of the nuclei parafascicularis thalami. The regions associated with ipsiversive tilt of SVV were located in more inferior regions, involving structures such as the nuclei endymalis thalami, inferior parts of the nuclei parafascicularis thalami, and also small parts of the junction zone of the nuclei ruber tegmenti and brachium conjunctivum. CONCLUSIONS: Our data indicate that there are 2 anatomically distinct graviceptive signal processing mechanisms within the vestibular network in humans that lead, when damaged, to a vestibular tone imbalance either to the contraversive or to the ipsiversive side.
Authors: Suzanne R Babyar; Anna Smeragliuolo; Fatimah M Albazron; David Putrino; Michael Reding; Aaron D Boes Journal: Stroke Date: 2019-05 Impact factor: 7.914
Authors: Sandra Becker-Bense; Hans-Georg Buchholz; Bernhard Baier; Mathias Schreckenberger; Peter Bartenstein; Andreas Zwergal; Thomas Brandt; Marianne Dieterich Journal: PLoS One Date: 2016-11-08 Impact factor: 3.240