Aurélie Mbeutcha1,2, Ilaria Lucca1,3, Vitaly Margulis4, Jose A Karam5, Christopher G Wood5, Michela de Martino1, Romain Mathieu1,6, Andrea Haitel7, Evanguelos Xylinas8, Luis Kluth9, Morgan Rouprêt10, Pierre I Karakiewicz11, Alberto Briganti12, Michael Rink9, Malte Rieken1,13, Alon Z Weizer14, Jay D Raman15, Nathalie Rioux-Leclecq16, Christian Bolenz17, Karim Bensalah6, Yair Lotan4, Christian Seitz1, Mesut Remzi18, Shahrokh F Shariat19,20,21, Tobias Klatte1. 1. Department of Urology, Vienna General Hospital, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. 2. Department of Urology, Hôpital Archet 2, Centre Hospitalier Universitaire de Nice, University of Nice Sophia-Antipolis, Nice, France. 3. Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. 4. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. 5. Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. 6. Department of Urology, Rennes University Hospital, Rennes, France. 7. Department of Pathology, Medical University of Vienna, Vienna, Austria. 8. Department of Urology Cochin Hospital, APHP, Paris Descartes University, Paris, France. 9. Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 10. Department of Urology, Pitié-Salpétrière, Assistance-Publique Hôpitaux de Paris and Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France. 11. Department of Urology, University of Montreal, Montreal, QC, Canada. 12. Dipartimento di Urologia, Ospedale S. Raffaele, Università Vita-Salute, Milan, Italy. 13. Department of Urology, University Hospital Basel, Basel, Switzerland. 14. Department of Urology, University of Michigan, Ann Arbor, MI, USA. 15. Division of Urology, Penn State Milton S.Hershey Medical Center, Hershey, PA, USA. 16. Department of Pathology, University of Rennes, Rennes, France. 17. Department of Urology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany. 18. Department of Urology, Landeskrankenhaus Weinviertel-Korneuburg, Korneuburg, Austria. 19. Department of Urology, Vienna General Hospital, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. sfshariat@gmail.com. 20. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. sfshariat@gmail.com. 21. Department of Urology, Weill Cornell Medical College, New York, NY, USA. sfshariat@gmail.com.
Abstract
BACKGROUND: Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients. METHODS: Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models. RESULTS: ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively). CONCLUSIONS: ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.
BACKGROUND:Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients. METHODS: Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models. RESULTS:ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively). CONCLUSIONS:ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.
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Authors: Ilaria Lucca; Wassim Kassouf; Anil Kapoor; Adrian Fairey; Ricardo A Rendon; Jonathan I Izawa; Peter C Black; Harun Fajkovic; Christian Seitz; Mesut Remzi; Peter Nyirády; Morgan Rouprêt; Vitaly Margulis; Yair Lotan; Michela de Martino; Sebastian L Hofbauer; Pierre I Karakiewicz; Alberto Briganti; Giacomo Novara; Shahrokh F Shariat; Tobias Klatte Journal: BJU Int Date: 2015-03-06 Impact factor: 5.588