Literature DB >> 26656695

Suppression of NYVAC Infection in HeLa Cells Requires RNase L but Is Independent of Protein Kinase R Activity.

Mercedes Fernández-Escobar1, José Luis Nájera2, Sara Baldanta1, Dolores Rodriguez2, Michael Way3, Mariano Esteban2, Susana Guerra4.   

Abstract

Protein kinase R (PKR) and RNase L are host cell components that function to contain viral spread after infections. In this study, we analyzed the role of both proteins in the abortive infection of human HeLa cells with the poxvirus strain NYVAC, for which an inhibition of viral A27L and B5R gene expression is described. Specifically, the translation of these viral genes is independent of PKR activation, but their expression is dependent on the RNase L activity.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26656695      PMCID： PMC4734000          DOI： 10.1128/JVI.02576-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  Identification of second-site mutations that enhance release and spread of vaccinia virus.

Authors:  Ehud Katz; Elizabeth Wolffe; Bernard Moss
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

2.  Role for the vaccinia virus A36R outer envelope protein in the formation of virus-tipped actin-containing microvilli and cell-to-cell virus spread.

Authors:  E J Wolffe; A S Weisberg; B Moss
Journal:  Virology       Date:  1998-04-25       Impact factor: 3.616

Review 3.  The role of signalling and the cytoskeleton during Vaccinia Virus egress.

Authors:  Flavia Leite; Michael Way
Journal:  Virus Res       Date:  2015-02-11       Impact factor: 3.303

4.  Vaccinia virus intracellular movement is associated with microtubules and independent of actin tails.

Authors:  B M Ward; B Moss
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

5.  Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling.

Authors:  F Frischknecht; V Moreau; S Röttger; S Gonfloni; I Reckmann; G Superti-Furga; M Way
Journal:  Nature       Date:  1999-10-28       Impact factor: 49.962

6.  Interactions between vaccinia virus IEV membrane proteins and their roles in IEV assembly and actin tail formation.

Authors:  S Röttger; F Frischknecht; I Reckmann; G L Smith; M Way
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

7.  Functional analysis of vaccinia virus B5R protein: essential role in virus envelopment is independent of a large portion of the extracellular domain.

Authors:  E Herrera; M M Lorenzo; R Blasco; S N Isaacs
Journal:  J Virol       Date:  1998-01       Impact factor: 5.103

8.  Roles of vaccinia virus EEV-specific proteins in intracellular actin tail formation and low pH-induced cell-cell fusion.

Authors:  C M Sanderson; F Frischknecht; M Way; M Hollinshead; G L Smith
Journal:  J Gen Virol       Date:  1998-06       Impact factor: 3.891

Review 9.  Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interferon action.

Authors:  R H Silverman
Journal:  J Interferon Res       Date:  1994-06

10.  The extracellular domain of vaccinia virus protein B5R affects plaque phenotype, extracellular enveloped virus release, and intracellular actin tail formation.

Authors:  E Mathew; C M Sanderson; M Hollinshead; G L Smith
Journal:  J Virol       Date:  1998-03       Impact factor: 5.103
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  1 in total

1.  Exacerbated Apoptosis of Cells Infected with Infectious Bursal Disease Virus upon Exposure to Interferon Alpha.

Authors:  Liliana L Cubas-Gaona; Elisabet Diaz-Beneitez; Marina Ciscar; José F Rodríguez; Dolores Rodríguez
Journal:  J Virol       Date:  2018-05-14       Impact factor: 5.103
  1 in total

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