| Literature DB >> 26656478 |
E Susan Amirian, Georgina N Armstrong, Renke Zhou, Ching C Lau, Elizabeth B Claus, Jill S Barnholtz-Sloan, Dora Il'yasova, Joellen Schildkraut, Francis Ali-Osman, Siegal Sadetzki, Christoffer Johansen, Richard S Houlston, Robert B Jenkins, Daniel Lachance, Sara H Olson, Jonine L Bernstein, Ryan T Merrell, Margaret R Wrensch, Faith G Davis, Rose Lai, Sanjay Shete, Christopher I Amos, Michael E Scheurer, Kenneth Aldape, Irina Alafuzoff, Thomas Brännström, Helle Broholm, Peter Collins, Caterina Giannini, Marc Rosenblum, Tarik Tihan, Beatrice S Melin, Melissa L Bondy.
Abstract
Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity of tumor subtypes, and retrospective exposure assessment. Here, we briefly describe the Glioma International Case-Control (GICC) Study (recruitment, 2010-2013), a study being conducted by the Genetic Epidemiology of Glioma International Consortium that integrates data from multiple data collection sites, uses a common protocol and questionnaire, and includes biospecimen collection. To our knowledge, the GICC Study is the largest glioma study to date that includes collection of blood samples, which will allow for genetic analysis and interrogation of gene-environment interactions.Entities:
Keywords: cancer; case-control studies; glioblastoma; glioma; methodology; study profile
Mesh：
Year: 2015 PMID： 26656478 PMCID： PMC4706682 DOI： 10.1093/aje/kwv235
Source DB: PubMed Journal: Am J Epidemiol ISSN： 0002-9262 Impact factor: 4.897