Lidia Mínguez-Alarcón1, Yu-Han Chiu2, Carmen Messerlian3, Paige L Williams4, Mary E Sabatini5, Thomas L Toth6, Jennifer B Ford3, Antonia M Calafat7, Russ Hauser8. 1. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. Electronic address: lminguez@hsph.harvard.edu. 2. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 3. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 4. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 5. Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts. 6. Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 7. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia. 8. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Abstract
OBJECTIVE: To explore the relationship between urinary paraben concentrations and IVF outcomes among women attending an academic fertility center. DESIGN: Prospective cohort study. SETTING: Fertility clinic in a hospital setting. PATIENT(S): A total of 245 women contributing 356 IVF cycles. INTERVENTION(S): None. Quantification of urinary concentrations of parabens by isotope-dilution tandem mass spectrometry, and assessment of clinical endpoints of IVF treatments abstracted from electronic medical records at the academic fertility center. MAIN OUTCOME MEASURE(S): Total and mature oocyte counts, proportion of high-quality embryos, fertilization rates, and rates of implantation, clinical pregnancy, and live births. RESULT(S): The geometric means of the urinary concentrations of methylparaben, propylparaben, and butylparaben in our study population were 133, 24, and 1.5 μg/L, respectively. In models adjusted for age, body mass index, race/ethnicity, smoking status, and primary infertility diagnosis, urinary methylparaben, propylparaben, and butylparaben concentrations were not associated with IVF outcomes, specifically total and mature oocyte counts, proportion of high embryo quality, and fertilization rates. Moreover, no significant associations were found between urinary paraben concentrations and rates of implantation, clinical pregnancy, and live births. CONCLUSION(S): Urinary paraben concentrations were not associated with IVF outcomes among women undergoing infertility treatments.
OBJECTIVE: To explore the relationship between urinary paraben concentrations and IVF outcomes among women attending an academic fertility center. DESIGN: Prospective cohort study. SETTING: Fertility clinic in a hospital setting. PATIENT(S): A total of 245 women contributing 356 IVF cycles. INTERVENTION(S): None. Quantification of urinary concentrations of parabens by isotope-dilution tandem mass spectrometry, and assessment of clinical endpoints of IVF treatments abstracted from electronic medical records at the academic fertility center. MAIN OUTCOME MEASURE(S): Total and mature oocyte counts, proportion of high-quality embryos, fertilization rates, and rates of implantation, clinical pregnancy, and live births. RESULT(S): The geometric means of the urinary concentrations of methylparaben, propylparaben, and butylparaben in our study population were 133, 24, and 1.5 μg/L, respectively. In models adjusted for age, body mass index, race/ethnicity, smoking status, and primary infertility diagnosis, urinary methylparaben, propylparaben, and butylparaben concentrations were not associated with IVF outcomes, specifically total and mature oocyte counts, proportion of high embryo quality, and fertilization rates. Moreover, no significant associations were found between urinary paraben concentrations and rates of implantation, clinical pregnancy, and live births. CONCLUSION(S): Urinary paraben concentrations were not associated with IVF outcomes among women undergoing infertility treatments.
Authors: Jennifer Yland; Carmen Messerlian; Lidia Mínguez-Alarcón; Jennifer B Ford; Russ Hauser; Paige L Williams Journal: Hum Reprod Date: 2019-03-01 Impact factor: 6.918
Authors: Anna Z Pollack; Sunni L Mumford; Jenna R Krall; Andrea E Carmichael; Lindsey A Sjaarda; Neil J Perkins; Kurunthachalam Kannan; Enrique F Schisterman Journal: Environ Int Date: 2018-08-10 Impact factor: 9.621
Authors: Lidia Mínguez-Alarcón; Yu-Han Chiu; Feiby L Nassan; Paige L Williams; John Petrozza; Jennifer B Ford; Antonia M Calafat; Russ Hauser; Jorge E Chavarro Journal: Sci Total Environ Date: 2019-05-02 Impact factor: 7.963
Authors: Lidia Mínguez-Alarcón; Carmen Messerlian; Andrea Bellavia; Audrey J Gaskins; Yu-Han Chiu; Jennifer B Ford; Alexandra R Azevedo; John C Petrozza; Antonia M Calafat; Russ Hauser; Paige L Williams Journal: Environ Int Date: 2019-02-28 Impact factor: 9.621
Authors: Rosie M Martinez; Russ Hauser; Liming Liang; Abdallah Mansur; Michal Adir; Laura Dioni; Catherine Racowsky; Valentina Bollati; Andrea A Baccarelli; Ronit Machtinger Journal: Environ Int Date: 2018-11-24 Impact factor: 9.621