PURPOSE: To investigate whether short-term nonsteroidal anti-inflammatory drug (NSAID) pretreatment on the day of surgery inhibits prostaglandin release. Previous studies detected elevated prostaglandin levels after femtosecond laser treatment and identified them as a potential mediator for laser-induced miosis. METHODS: Patients underwent either image-guided femtosecond laser cataract surgery or conventional cataract surgery (n = 75). Half of the eyes per group received topical NSAID treatment on the day of surgery. Aqueous humor was collected from all patients. ELISA measurements were performed to detect aqueous humor prostaglandin levels. RESULTS:Femtosecond laser cataract surgery led to higher prostaglandin levels than conventional cataract surgery (P = .007). In both groups, NSAID pretreatment led to reduced prostaglandin release. In the femtosecond laser group, patients pretreated with NSAIDs had significantly lower prostaglandin values (65.3 ± 13.2 pg/mL) than patients not pretreated with NSAIDs (294.4 ± 66.5 pg/mL) (P = .0009). CONCLUSIONS: The short-term NSAID treatment prevented prostaglandin release in patients treated with image-guided femtosecond laser. Therefore, it has potential to limit intraoperative laser-induced miosis. Copyright 2015, SLACK Incorporated.
RCT Entities:
PURPOSE: To investigate whether short-term nonsteroidal anti-inflammatory drug (NSAID) pretreatment on the day of surgery inhibits prostaglandin release. Previous studies detected elevated prostaglandin levels after femtosecond laser treatment and identified them as a potential mediator for laser-induced miosis. METHODS:Patients underwent either image-guided femtosecond laser cataract surgery or conventional cataract surgery (n = 75). Half of the eyes per group received topical NSAID treatment on the day of surgery. Aqueous humor was collected from all patients. ELISA measurements were performed to detect aqueous humor prostaglandin levels. RESULTS: Femtosecond laser cataract surgery led to higher prostaglandin levels than conventional cataract surgery (P = .007). In both groups, NSAID pretreatment led to reduced prostaglandin release. In the femtosecond laser group, patients pretreated with NSAIDs had significantly lower prostaglandin values (65.3 ± 13.2 pg/mL) than patients not pretreated with NSAIDs (294.4 ± 66.5 pg/mL) (P = .0009). CONCLUSIONS: The short-term NSAID treatment prevented prostaglandin release in patients treated with image-guided femtosecond laser. Therefore, it has potential to limit intraoperative laser-induced miosis. Copyright 2015, SLACK Incorporated.
Authors: Vasilios F Diakonis; Apostolos G Anagnostopoulos; Angeliki Moutsiopoulou; Nilufer Yesilirmak; Florence Cabot; Daniel P Waren; Terrence P O'Brien; Sonia H Yoo; Robert J Weinstock; Kendall E Donaldson Journal: J Ophthalmol Date: 2018-07-10 Impact factor: 1.909
Authors: Yu-Chi Liu; Melina Setiawan; Jia Ying Chin; Benjamin Wu; Hon Shing Ong; Ecosse Lamoureux; Jodhbir S Mehta Journal: Front Med (Lausanne) Date: 2021-12-17