| Literature DB >> 26651288 |
Shana Elbaum-Garfinkle1, Clifford P Brangwynne2.
Abstract
Recent advances suggest that phase transitions of proteins into liquid or hydrogel states could underlie pathological protein aggregation associated with neurodegenerative disease. In a recent issue of Neuron, Murakami et al. (2015) demonstrate that ALS-associated FUS mutations abrogate the reversibility of condensed liquids and/or hydrogels, leading to neurotoxicity in C. elegans.Entities:
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Year: 2015 PMID： 26651288 DOI： 10.1016/j.devcel.2015.11.014
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270