Literature DB >> 26647816

Short interfering RNA therapeutics: nanocarriers, prospects and limitations.

Neha Mehrotra1, Ravi Mani Tripathi2.   

Abstract

Since the first experiment depicting gene inhibition using RNA interference mechanism, extensive research has been carried out to design targeted delivery systems that use short interfering RNAs (siRNAs) for gene expression regulation. Although several siRNAs loaded nanoparticle systems have reached clinical trial stage, cellular uptake, reticuloendothelial entrapment and endosomal escape still limit the efficacy of these drugs considerably. This review discusses about the RNA interference mechanism, nanostructures being used as non-viral vectors for targeted delivery, limitations of the common delivery systems and the current siRNA-loaded nanoparticle formulations undergoing clinical testing.

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Year:  2015        PMID： 26647816     DOI： 10.1049/iet-nbt.2015.0018

Source DB:  PubMed          Journal:  IET Nanobiotechnol        ISSN： 1751-8741            Impact factor:   1.847


  16 in total

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Authors:  Sharath Kumar Hari; Ankita Gauba; Neeraj Shrivastava; Ravi Mani Tripathi; Sudhir Kumar Jain; Akhilesh Kumar Pandey
Journal:  Drug Deliv Transl Res       Date:  2022-06-21       Impact factor: 4.617

2.  Mesenchymal Stem Cell-Derived Exosomes: A Potential Therapeutic Avenue in Knee Osteoarthritis.

Authors:  Madhan Jeyaraman; Sathish Muthu; Arun Gulati; Naveen Jeyaraman; Prajwal G S; Rashmi Jain
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Review 3.  Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges.

Authors:  Dinh Ha; Ningning Yang; Venkatareddy Nadithe
Journal:  Acta Pharm Sin B       Date:  2016-03-08       Impact factor: 11.413

Review 4.  Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases.

Authors:  Guohua Lou; Zhi Chen; Min Zheng; Yanning Liu
Journal:  Exp Mol Med       Date:  2017-06-16       Impact factor: 8.718

5.  Low-density lipoprotein-coupled micelles with reduction and pH dual sensitivity for intelligent co-delivery of paclitaxel and siRNA to breast tumor.

Authors:  Wen-Jing Zhu; Shu-di Yang; Chen-Xi Qu; Qiao-Ling Zhu; Wei-Liang Chen; Fang Li; Zhi-Qiang Yuan; Yang Liu; Ben-Gang You; Xue-Nong Zhang
Journal:  Int J Nanomedicine       Date:  2017-04-26

6.  Enzyme Mimetic Activity of ZnO-Pd Nanosheets Synthesized via a Green Route.

Authors:  Ravi Mani Tripathi; Dohee Ahn; Yeong Mok Kim; Sang J Chung
Journal:  Molecules       Date:  2020-06-02       Impact factor: 4.411

7.  Nanotechnology for Treatment of Glioblastoma Multiforme.

Authors:  Justin S Michael; Bong-Seop Lee; Miqin Zhang; John S Yu
Journal:  J Transl Int Med       Date:  2018-10-09

8.  Facile Synthesis of Triangular and Hexagonal Anionic Gold Nanoparticles and Evaluation of Their Cytotoxicity.

Authors:  R M Tripathi; Sun-Young Yoon; Dohee Ahn; Sang J Chung
Journal:  Nanomaterials (Basel)       Date:  2019-12-12       Impact factor: 5.076

Review 9.  Extracellular Vesicles from Mesenchymal Stem Cells as Potential Treatments for Osteoarthritis.

Authors:  Nur Azira Mohd Noor; Asma Abdullah Nurul; Muhammad Rajaei Ahmad Mohd Zain; Wan Khairunnisaa Wan Nor Aduni; Maryam Azlan
Journal:  Cells       Date:  2021-05-22       Impact factor: 6.600

10.  Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells.

Authors:  Akhil Srivastava; Narsireddy Amreddy; Anish Babu; Janani Panneerselvam; Meghna Mehta; Ranganayaki Muralidharan; Allshine Chen; Yan Daniel Zhao; Mohammad Razaq; Natascha Riedinger; Hogyoung Kim; Shaorong Liu; Si Wu; Asim B Abdel-Mageed; Anupama Munshi; Rajagopal Ramesh
Journal:  Sci Rep       Date:  2016-12-12       Impact factor: 4.379
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